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CATH Superfamily 3.40.50.10980

Nibrin, BRCT2 domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nibrin, BRCT2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Nibrin, BRCT2 domain

This superfamily includes the second BRCT domain, BRCT2, of Nibrin (Nijmegen breakage syndrome protein Nbs1), a component of the MRN (Mre11-Rad50-Nbs1) complex that is involved in the DNA damage response. This domain (BRCT2) is located downstream from BRCT1 domain and has no significant amino acid sequence homology to other BRCT domains. However, it has the alpha/beta topology characteristic of BRCT domains in other proteins, but differs markedly in having a disordered long loop inserted between alpha beta strand and an alpha helix. BRCT2 is essential for an MDC1-dependent relocalisation of Nbs1 to DNA damage sites PMID:18582474.

INTERPRO:IPR032429, PFAM:PF16508,DOI:10.1016/j.jmb.2008.05.087

GO Diversity

Unique GO annotations
53 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
638 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Function
Unique EC:
Unique GO: 53
Taxonomy
Unique Species: 638