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CATH Superfamily 3.40.50.10860

Leucine Dehydrogenase, chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine Dehydrogenase, chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Quinate/shikimate dehydrogenase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Quinate/shikimate dehydrogenase. [EC: 1.1.1.282]
(1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.
  • The enzyme is found in bacteria (mostly, but not exclusively, Gram- positive bacteria), fungi, and plants.
  • It participates in the degradation of quinate and shikimate with a strong preference for NAD+ as a cofactor.
  • While the enzyme can act on both quinate and shikimate, activity is higher with the former.
 10220 A0A026UF40 A0A026UF40 A0A026UF40 A0A026UF40 A0A026UF40 A0A026UF40 A0A026UF40 A0A026UF40 A0A026UF40 A0A026UF40
(10210 more...)
Shikimate dehydrogenase. [EC: 1.1.1.25]
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
  • NAD(+) cannot replace NADP(+).
  • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
 230 A0A0D6J6X6 A0A0D6J6X6 A0A0D6J6X6 A0A0E1R4C9 A0A0E1R4C9 A0A0E1R4C9 A0A0E1R4C9 A0A0E1R4C9 A0A0E1R4C9 A0A0E1R4C9
(220 more...)
Quinate dehydrogenase. [EC: 1.1.1.24]
Quinate + NAD(+) = 3-dehydroquinate + NADH.
  • The enzyme is specific for quinate as substrate; phenylpyruvate, phenylalanine, cinnamate and shikimate will not act as substrates.
  • NAD(+) cannot be replaced by NADP(+).
 27 A0A072Z5G5 A0A072Z5G5 A0A072Z5G5 A0A072Z5G5 A0A072Z5G5 A0A0F6Z3Y2 A0A0F6Z3Y2 A0A0F6Z3Y2 A0A0F6Z3Y2 A0A0F6Z3Y2
(17 more...)