The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Translation initiation factor eif-2b; domain 2
".
FunFam 9: Translation initiation factor eIF2B subunit
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P32502 (/IPI) P32502 (/IPI) P32502 (/IPI) Q9UT76 (/IPI) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
3 | P32502 (/IGI) P32502 (/IGI) P32502 (/IGI) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
3 | P32502 (/IPI) P32502 (/IPI) P32502 (/IPI) |
|
Enzyme regulator activity GO:0030234
Binds to and modulates the activity of an enzyme.
|
3 | P32502 (/IGI) P32502 (/IGI) P32502 (/IGI) |
|
Enzyme regulator activity GO:0030234
Binds to and modulates the activity of an enzyme.
|
3 | P32502 (/IMP) P32502 (/IMP) P32502 (/IMP) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
1 | Q9UT76 (/IDA) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
1 | O76863 (/ISS) |
|
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q9UT76 (/IDA) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | Q54EY2 (/IC) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
3 | P32502 (/IDA) P32502 (/IDA) P32502 (/IDA) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
3 | P32502 (/IGI) P32502 (/IGI) P32502 (/IGI) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
3 | P32502 (/IMP) P32502 (/IMP) P32502 (/IMP) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
3 | P32502 (/IPI) P32502 (/IPI) P32502 (/IPI) |
|
Cytoplasmic translational initiation GO:0002183
The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | Q9UT76 (/IDA) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | O76863 (/ISS) |
|
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | O76863 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | P32502 (/HDA) P32502 (/HDA) P32502 (/HDA) Q9UT76 (/HDA) |
|
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
4 | P32502 (/IDA) P32502 (/IDA) P32502 (/IDA) Q9UT76 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | P32502 (/HDA) P32502 (/HDA) P32502 (/HDA) |
|
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
3 | P32502 (/IGI) P32502 (/IGI) P32502 (/IGI) |
|
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
3 | P32502 (/IMP) P32502 (/IMP) P32502 (/IMP) |
|
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
3 | P32502 (/IPI) P32502 (/IPI) P32502 (/IPI) |
|
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
|
3 | P32502 (/IDA) P32502 (/IDA) P32502 (/IDA) |
|
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
|
3 | P32502 (/IPI) P32502 (/IPI) P32502 (/IPI) |
|
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
2 | O76863 (/ISS) Q54EY2 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O76863 (/ISS) |