The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Toll/interleukin-1 receptor homology (TIR) domain
".
FunFam 34: Tehao
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Toll binding GO:0005121
Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor.
|
3 | Q58S70 (/IPI) Q58S71 (/IPI) Q58S76 (/IPI) |
|
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
|
3 | Q58S70 (/IDA) Q58S71 (/IDA) Q58S76 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
3 | Q58S70 (/IPI) Q58S71 (/IPI) Q58S76 (/IPI) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of antimicrobial peptide biosynthetic process GO:0002807
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.
|
3 | Q58S70 (/IMP) Q58S71 (/IMP) Q58S76 (/IMP) |
|
Positive regulation of antifungal peptide biosynthetic process GO:0006967
Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.
|
3 | Q58S70 (/TAS) Q58S71 (/TAS) Q58S76 (/TAS) |
|
Toll signaling pathway GO:0008063
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q58S70 (/IDA) Q58S71 (/IDA) Q58S76 (/IDA) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
3 | Q58S70 (/IMP) Q58S71 (/IMP) Q58S76 (/IMP) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
