The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Toll/interleukin-1 receptor homology (TIR) domain
".
FunFam 20: Blast:Protein toll
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Toll binding GO:0005121
Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor.
|
3 | Q9NBK8 (/IPI) Q9VJX9 (/IPI) Q9XZF9 (/IPI) |
|
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
|
3 | Q9NBK8 (/IDA) Q9VJX9 (/IDA) Q9XZF9 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
3 | Q9NBK8 (/IPI) Q9VJX9 (/IPI) Q9XZF9 (/IPI) |
|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Cytokine receptor activity GO:0004896
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P08953 (/IPI) P08953 (/IPI) |
|
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
|
2 | P08953 (/IPI) P08953 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P08953 (/IPI) P08953 (/IPI) |
|
TIR domain binding GO:0070976
Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.
|
2 | P08953 (/IPI) P08953 (/IPI) |
There are 30 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Toll signaling pathway GO:0008063
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
5 | P08953 (/IDA) P08953 (/IDA) Q9NBK8 (/IDA) Q9VJX9 (/IDA) Q9XZF9 (/IDA) |
|
Positive regulation of antimicrobial peptide biosynthetic process GO:0002807
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.
|
3 | Q9NBK8 (/IMP) Q9VJX9 (/IMP) Q9XZF9 (/IMP) |
|
Toll signaling pathway GO:0008063
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | P08953 (/IGI) P08953 (/IGI) Q9VJX9 (/IGI) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
3 | Q9NBK8 (/IMP) Q9VJX9 (/IMP) Q9XZF9 (/IMP) |
|
Antifungal innate immune response GO:0061760
An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
|
3 | P08953 (/IMP) P08953 (/IMP) Q9VJX9 (/IMP) |
|
Positive regulation of antimicrobial peptide production GO:0002225
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Defense response to oomycetes GO:0002229
Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Positive regulation of antifungal peptide production GO:0002804
Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Positive regulation of antifungal peptide production GO:0002804
Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.
|
2 | P08953 (/IGI) P08953 (/IGI) |
|
Positive regulation of antifungal peptide biosynthetic process GO:0006967
Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.
|
2 | Q9NBK8 (/TAS) Q9XZF9 (/TAS) |
|
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Toll signaling pathway GO:0008063
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Toll signaling pathway GO:0008063
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P08953 (/TAS) P08953 (/TAS) |
|
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
2 | P08953 (/IGI) P08953 (/IGI) |
|
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Synaptic target inhibition GO:0016201
The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
2 | P08953 (/IGI) P08953 (/IGI) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Positive regulation of hemocyte proliferation GO:0035208
Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Negative regulation of multicellular organism growth GO:0040015
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
2 | P08953 (/IGI) P08953 (/IGI) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
2 | P08953 (/IMP) P08953 (/IMP) |
|
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Antifungal innate immune response GO:0061760
An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Regulation of embryonic pattern specification GO:1902875
Any process that modulates the frequency, rate or extent of embryonic pattern specification.
|
2 | P08953 (/IMP) P08953 (/IMP) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P08953 (/HDA) P08953 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P08953 (/TAS) P08953 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
|
2 | P08953 (/IDA) P08953 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | P08953 (/IPI) P08953 (/IPI) |
