The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Toll/interleukin-1 receptor homology (TIR) domain
".
FunFam 19: 18w protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
5 | A1ZBR2 (/ISS) Q24591 (/ISS) Q2XXS4 (/ISS) Q7JPR9 (/ISS) Q961H0 (/ISS) |
Neurotrophin receptor activity GO:0005030
Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity.
|
1 | Q7KIN0 (/IMP) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q24591 (/IPI) |
Signaling pattern recognition receptor activity GO:0008329
Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.
|
1 | Q7KIN0 (/IC) |
Virion binding GO:0046790
Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope.
|
1 | Q7KIN0 (/IDA) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Axis elongation GO:0003401
The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.
|
5 | A1ZBR2 (/IGI) Q24591 (/IGI) Q2XXS4 (/IGI) Q7JPR9 (/IGI) Q961H0 (/IGI) |
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
5 | A1ZBR2 (/IEP) Q24591 (/IEP) Q2XXS4 (/IEP) Q7JPR9 (/IEP) Q961H0 (/IEP) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
5 | A1ZBR2 (/IDA) Q24591 (/IDA) Q2XXS4 (/IDA) Q7JPR9 (/IDA) Q961H0 (/IDA) |
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
5 | A1ZBR2 (/TAS) Q24591 (/TAS) Q2XXS4 (/TAS) Q7JPR9 (/TAS) Q961H0 (/TAS) |
Ovarian follicle cell migration GO:0007297
The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster.
|
5 | A1ZBR2 (/IMP) Q24591 (/IMP) Q2XXS4 (/IMP) Q7JPR9 (/IMP) Q961H0 (/IMP) |
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
|
5 | A1ZBR2 (/HMP) Q24591 (/HMP) Q2XXS4 (/HMP) Q7JPR9 (/HMP) Q961H0 (/HMP) |
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
|
5 | A1ZBR2 (/IMP) Q24591 (/IMP) Q2XXS4 (/IMP) Q7JPR9 (/IMP) Q961H0 (/IMP) |
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
|
5 | A1ZBR2 (/IMP) Q24591 (/IMP) Q2XXS4 (/IMP) Q7JPR9 (/IMP) Q961H0 (/IMP) |
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
|
5 | A1ZBR2 (/TAS) Q24591 (/TAS) Q2XXS4 (/TAS) Q7JPR9 (/TAS) Q961H0 (/TAS) |
Eggshell formation GO:0030703
Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration.
|
5 | A1ZBR2 (/IMP) Q24591 (/IMP) Q2XXS4 (/IMP) Q7JPR9 (/IMP) Q961H0 (/IMP) |
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
|
5 | A1ZBR2 (/IGI) Q24591 (/IGI) Q2XXS4 (/IGI) Q7JPR9 (/IGI) Q961H0 (/IGI) |
Cell surface pattern recognition receptor signaling pathway GO:0002752
Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
|
1 | Q7KIN0 (/IC) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q7KIN0 (/IMP) |
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q7KIN0 (/IMP) |
Regulation of defense response to virus GO:0050688
Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
|
1 | Q7KIN0 (/IMP) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
1 | Q7KIN0 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | A1ZBR2 (/IDA) Q24591 (/IDA) Q2XXS4 (/IDA) Q7JPR9 (/IDA) Q961H0 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | A1ZBR2 (/ISS) Q24591 (/ISS) Q2XXS4 (/ISS) Q7JPR9 (/ISS) Q961H0 (/ISS) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q7KIN0 (/IDA) |