The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Toll/interleukin-1 receptor homology (TIR) domain
".
FunFam 11: single Ig IL-1-related receptor isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | A1L1Q8 (/IPI) A4JYJ7 (/IPI) K9K3G6 (/IPI) Q6IA17 (/IPI) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
3 | Q4V892 (/ISS) Q9JLZ8 (/ISS) Q9JLZ8 (/ISS) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
3 | A1L1Q8 (/IMP) A4JYJ7 (/IMP) K9K3G6 (/IMP) |
|
Negative regulation of cytokine-mediated signaling pathway GO:0001960
Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
|
2 | Q9JLZ8 (/IMP) Q9JLZ8 (/IMP) |
|
Negative regulation of cytokine-mediated signaling pathway GO:0001960
Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
|
2 | Q4V892 (/ISS) Q6IA17 (/ISS) |
|
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
|
2 | Q9JLZ8 (/IMP) Q9JLZ8 (/IMP) |
|
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
|
2 | Q4V892 (/ISS) Q6IA17 (/ISS) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | Q9JLZ8 (/ISO) Q9JLZ8 (/ISO) |
|
Negative regulation of chemokine biosynthetic process GO:0045079
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
2 | Q9JLZ8 (/IMP) Q9JLZ8 (/IMP) |
|
Negative regulation of chemokine biosynthetic process GO:0045079
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
2 | Q4V892 (/ISS) Q6IA17 (/ISS) |
|
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
|
1 | Q6IA17 (/TAS) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | Q6IA17 (/IMP) |
|
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | Q6IA17 (/TAS) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
3 | A1L1Q8 (/IDA) A4JYJ7 (/IDA) K9K3G6 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | Q4V892 (/ISS) Q9JLZ8 (/ISS) Q9JLZ8 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | Q9JLZ8 (/ISO) Q9JLZ8 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q6IA17 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q6IA17 (/IMP) |
