The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CDGSH iron-sulfur domain, mitoNEET-type
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: CDGSH iron-sulfur domain-containing protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
26 B5X8S2 (/ISS) B5X8S2 (/ISS) B9EPI1 (/ISS) B9EPI1 (/ISS) C1BGG0 (/ISS) C1BI29 (/ISS) C1C524 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS)
(16 more)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
26 B5X8S2 (/ISS) B5X8S2 (/ISS) B9EPI1 (/ISS) B9EPI1 (/ISS) C1BGG0 (/ISS) C1BI29 (/ISS) C1C524 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS)
(16 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
15 Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI) Q9NZ45 (/IPI)
(5 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
13 Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA)
(3 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI) Q8N5K1 (/IPI)
(3 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
13 Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA)
(3 more)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
13 Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA)
(3 more)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
2 Q9FLI7 (/IPI) Q9FLI7 (/IPI)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q91WS0 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q91WS0 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9CQB5 (/ISO)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
1 Q9CQB5 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Multicellular organism aging GO:0010259
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
38 B5X8S2 (/ISS) B5X8S2 (/ISS) B9EPI1 (/ISS) B9EPI1 (/ISS) C1BGG0 (/ISS) C1BI29 (/ISS) C1C524 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS)
(28 more)
Autophagy of mitochondrion GO:0000422
The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
25 B5X8S2 (/ISS) B5X8S2 (/ISS) B9EPI1 (/ISS) B9EPI1 (/ISS) C1BGG0 (/ISS) C1BI29 (/ISS) C1C524 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS)
(15 more)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
25 B5X8S2 (/ISS) B5X8S2 (/ISS) B9EPI1 (/ISS) B9EPI1 (/ISS) C1BGG0 (/ISS) C1BI29 (/ISS) C1C524 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS)
(15 more)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
13 Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP) Q8N5K1 (/IMP)
(3 more)
Leaf senescence GO:0010150
The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism.
2 Q9FLI7 (/IMP) Q9FLI7 (/IMP)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
2 Q9FLI7 (/IMP) Q9FLI7 (/IMP)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
2 Q9FLI7 (/IMP) Q9FLI7 (/IMP)
Autophagy of mitochondrion GO:0000422
The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
1 Q9CQB5 (/IMP)
Multicellular organism aging GO:0010259
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
1 Q9CQB5 (/IMP)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q9CQB5 (/ISO)
Regulation of cellular respiration GO:0043457
Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.
1 Q91WS0 (/IMP)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
48 A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA) A0A024QZN7 (/IDA)
(38 more)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
38 B5X8S2 (/ISS) B5X8S2 (/ISS) B9EPI1 (/ISS) B9EPI1 (/ISS) C1BGG0 (/ISS) C1BI29 (/ISS) C1C524 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS)
(28 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
25 B5X8S2 (/ISS) B5X8S2 (/ISS) B9EPI1 (/ISS) B9EPI1 (/ISS) C1BGG0 (/ISS) C1BI29 (/ISS) C1C524 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS) Q05B71 (/ISS)
(15 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
17 D6RCF4 (/IDA) D6RCF4 (/IDA) D6RCF4 (/IDA) D6RCF4 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA)
(7 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
16 Q91WS0 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA) Q9NZ45 (/HDA)
(6 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
15 Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS) Q9NZ45 (/ISS)
(5 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
14 Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA)
(4 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
13 Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA) Q8N5K1 (/HDA)
(3 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
13 Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA)
(3 more)
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
13 Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA) Q8N5K1 (/IDA)
(3 more)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
2 Q91WS0 (/IDA) Q9CQB5 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
2 Q9FLI7 (/IDA) Q9FLI7 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
2 Q9FLI7 (/IDA) Q9FLI7 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q91WS0 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9CQB5 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q9CQB5 (/ISO)
Cytoplasmic side of mitochondrial outer membrane GO:0032473
The external (cytoplasmic) face of the mitochondrial outer membrane.
1 B0K020 (/IDA)
Cytoplasmic side of mitochondrial outer membrane GO:0032473
The external (cytoplasmic) face of the mitochondrial outer membrane.
1 Q91WS0 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9CQB5 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q9CQB5 (/ISO)
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
1 Q9CQB5 (/ISO)
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