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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 85: 2-heptyl-4(1H)-quinolone synthase subunit PqsC

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-heptyl-4(1H)-quinolone synthase. [EC: 2.3.1.230]
Octanoyl-CoA + 2-aminobenzoylacetate = 2-heptyl-4(1H)-quinolone + CoA + CO(2) + H(2)O.
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex.
  • The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue.
  • Together with the PqsB subunit, the proteins catalyze the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring.
 121 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3 A0A0H2Z7A3
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