The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: acetyl-CoA acetyltransferase, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
22 P17764 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA)
(12 more)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
6 Q8S4Y1 (/IGI) Q8S4Y1 (/IGI) Q8S4Y1 (/IGI) Q9FIK7 (/IGI) Q9FIK7 (/IGI) Q9FIK7 (/IGI)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
4 P24752 (/IMP) P24752 (/IMP) P24752 (/IMP) P24752 (/IMP)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
4 P24752 (/TAS) P24752 (/TAS) P24752 (/TAS) P24752 (/TAS)
C-acetyltransferase activity GO:0016453
Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule.
4 P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
3 Q86AD9 (/ISS) Q9UQW6 (/ISS) Q9W3N9 (/ISS)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
1 C8V4N2 (/ISA)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
1 Q8QZT1 (/ISO)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
1 C8VM21 (/RCA)
C-acetyltransferase activity GO:0016453
Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule.
1 Q8QZT1 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P17764 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q8QZT1 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P17764 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8QZT1 (/ISO)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 P17764 (/IPI)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 Q8QZT1 (/ISO)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
9 P41338 (/IMP) P41338 (/IMP) P41338 (/IMP) P41338 (/IMP) P41338 (/IMP) P41338 (/IMP) P41338 (/IMP) P41338 (/IMP) P41338 (/IMP)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
4 P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA)
Isoleucine catabolic process GO:0006550
The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
4 P24752 (/IMP) P24752 (/IMP) P24752 (/IMP) P24752 (/IMP)
Isoleucine catabolic process GO:0006550
The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
4 P24752 (/TAS) P24752 (/TAS) P24752 (/TAS) P24752 (/TAS)
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
4 P24752 (/TAS) P24752 (/TAS) P24752 (/TAS) P24752 (/TAS)
Coenzyme A metabolic process GO:0015936
The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
4 P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA)
Coenzyme A biosynthetic process GO:0015937
The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
4 P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA)
Cholesterol esterification GO:0034435
A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.
4 P24752 (/TAS) P24752 (/TAS) P24752 (/TAS) P24752 (/TAS)
Acetyl-CoA catabolic process GO:0046356
The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
4 P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA)
Ketone body biosynthetic process GO:0046951
The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
4 P24752 (/TAS) P24752 (/TAS) P24752 (/TAS) P24752 (/TAS)
Ketone body catabolic process GO:0046952
The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.
4 P24752 (/IMP) P24752 (/IMP) P24752 (/IMP) P24752 (/IMP)
Ketone body catabolic process GO:0046952
The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.
4 P24752 (/TAS) P24752 (/TAS) P24752 (/TAS) P24752 (/TAS)
Ketone body metabolic process GO:1902224
The chemical reactions and pathways involving ketone body.
4 P24752 (/IC) P24752 (/IC) P24752 (/IC) P24752 (/IC)
Propionyl-CoA biosynthetic process GO:1902860
The chemical reactions and pathways resulting in the formation of propionyl-CoA.
4 P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA)
Pollen germination GO:0009846
The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture.
3 Q8S4Y1 (/IMP) Q8S4Y1 (/IMP) Q8S4Y1 (/IMP)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
3 Q8S4Y1 (/IMP) Q8S4Y1 (/IMP) Q8S4Y1 (/IMP)
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
3 Q8S4Y1 (/IMP) Q8S4Y1 (/IMP) Q8S4Y1 (/IMP)
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
2 Q86AD9 (/ISS) Q9UQW6 (/ISS)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 P17764 (/IEP)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
1 Q8QZT1 (/ISO)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
1 Q9W3N9 (/ISS)
Isoleucine catabolic process GO:0006550
The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
1 Q8QZT1 (/ISO)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 C8VM21 (/RCA)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q9W3N9 (/ISS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P17764 (/IEP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P17764 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P17764 (/IEP)
Coenzyme A metabolic process GO:0015936
The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
1 Q8QZT1 (/ISO)
Coenzyme A biosynthetic process GO:0015937
The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
1 Q8QZT1 (/ISO)
Fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539
A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
1 C8V4N2 (/ISA)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 P17764 (/IEP)
Acetyl-CoA catabolic process GO:0046356
The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
1 Q8QZT1 (/ISO)
Ketone body catabolic process GO:0046952
The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.
1 Q8QZT1 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P17764 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q8QZT1 (/ISO)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
1 P17764 (/IEP)
Metanephric proximal convoluted tubule development GO:0072229
The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule.
1 P17764 (/IEP)
Propionyl-CoA biosynthetic process GO:1902860
The chemical reactions and pathways resulting in the formation of propionyl-CoA.
1 Q8QZT1 (/ISO)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
11 A0A140VJX1 (/IDA) A0A140VJX1 (/IDA) A0A140VJX1 (/IDA) A0A140VJX1 (/IDA) P17764 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) P24752 (/IDA) Q22100 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P41338 (/HDA) P41338 (/HDA) P41338 (/HDA) P41338 (/HDA) P41338 (/HDA) P41338 (/HDA) P41338 (/HDA) P41338 (/HDA) P41338 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA) P41338 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 P24752 (/TAS) P24752 (/TAS) P24752 (/TAS) P24752 (/TAS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
4 Q86AD9 (/IDA) Q8S4Y1 (/IDA) Q8S4Y1 (/IDA) Q8S4Y1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q86AD9 (/IDA) Q8S4Y1 (/IDA) Q8S4Y1 (/IDA) Q8S4Y1 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P24752 (/HDA) P24752 (/HDA) P24752 (/HDA) P24752 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q8S4Y1 (/IDA) Q8S4Y1 (/IDA) Q8S4Y1 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8QZT1 (/HDA) Q9W3N9 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 C8V4N2 (/ISA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9W3N9 (/ISM)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8QZT1 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9W3N9 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P17764 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q8QZT1 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P17764 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8QZT1 (/ISO)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q9W3N9 (/ISM)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9UQW6 (/HDA)
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