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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 56: 3-oxoacyl-[acyl-carrier-protein] synthase 3

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Beta-ketoacyl-[acyl-carrier-protein] synthase III. [EC: 2.3.1.180]
Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier- protein] + CoA + CO(2).
  • Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria.
  • In contrast to EC 2.3.1.41 and EC 2.3.1.179, this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer.
  • In addition to the above reaction, the enzyme can also catalyze the reaction of EC 2.3.1.38, but to a much lesser extent.
  • Responsible for initiating both straight- and branched-chain fatty- acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism.
  • For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4--C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA.
 65 A0A0H3AHY6 A0A0H3AHY6 A0A0H3AHY6 A0A0H3AHY6 A0A0H3AHY6 A0A0H3AHY6 A0A0H3AHY6 A0A0H3Q0D0 A0A0H3Q0D0 A0A0H3Q0D0
(55 more...)
Anthraniloyl-CoA anthraniloyltransferase. [EC: 2.3.1.262]
Anthraniloyl-CoA + malonyl-CoA = 2-aminobenzoylacetyl-CoA + CoA + CO(2).
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl- 3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone.
  • The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl- CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone.
  • However, when EC 3.1.2.32 is present, it removes the CoA moiety from the product, forming the stable 2-aminobenzoylacetate.
 4 A0A2X1XXZ6 A0A2X1XXZ6 P20582 P20582
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