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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 32: Peroxisomal 3-ketoacyl-CoA thiolase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acetyl-CoA C-acyltransferase. [EC: 2.3.1.16]
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
  • The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation.
  • The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl- CoA shortened by two carbon atoms.
  • The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA.
  • In the second step the acyl group is transferred to CoA.
  • Most enzymes have a broad substrate range for the 3-oxoacyl-CoA.
  • cf. EC 2.3.1.9.
 12 A0A178UEC0 A0A178UEC0 A0A178VRP9 A0A178VRP9 A0A178W7T5 A0A178W7T5 Q56WD9 Q56WD9 Q570C8 Q570C8
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