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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Chalcone synthase 1

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Chalcone synthase. [EC: 2.3.1.74]
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2).
  • The enzyme catalyzes the first committed step in the biosynthesis of flavonoids.
  • It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
 65 A0A0R0LKP7 A0A0R0LKP7 A0A0R0LKP7 A0A2Z6ML51 A0A2Z6ML51 A0A384KNE5 A0A384KNE5 A0A384KNE5 A0A445M781 A0A445M781
(55 more...)
1,3,6,8-tetrahydroxynaphthalene synthase. [EC: 2.3.1.233]
5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO(2) + H(2)O.
  • Isolated from the fungus Colletotrichum lagenarium, and the bacteria Streptomyces coelicolor and Streptomyces peucetius.
  • It only uses malonyl-CoA, without invovement of acetyl-CoA.
 11 A0A2X2LVI7 A0A2X2LVI7 A0A2X2LVI7 B0FYK7 B1VLQ8 B1VLQ8 B1VLQ8 Q54240 Q54240 Q54240
(1 more...)
Curcumin synthase. [EC: 2.3.1.217]
Feruloyl-CoA + feruloylacetyl-CoA + H(2)O = 2 CoA + curcumin + CO(2).
  • A polyketide synthase from the plant Curcuma longa (turmeric).
  • Three isoforms exist, CURS1, CURS2 and CURS3.
  • While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well (see EC 2.3.1.219).
 6 A0A1X9IAM8 A0A1X9IAM8 C0SVZ6 C6L7V8 C6L7V9 C6L7V9
Demethoxycurcumin synthase. [EC: 2.3.1.219]
(1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H(2)O = 2 CoA + demethoxycurcumin + CO(2). (2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H(2)O = 2 CoA + bisdemethoxycurcumin + CO(2).
  • A polyketide synthase from the plant Curcuma longa (turmeric).
  • Three isoforms exist, CURS1, CURS2 and CURS3.
  • While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217), CURS3 can accept 4-coumaroyl-CoA equally well.
 4 A0A1X9IAM8 A0A1X9IAM8 C6L7V9 C6L7V9
3,5-dihydroxyphenylacetyl-CoA synthase. [EC: 2.3.1.246]
4 malonyl-CoA = (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO(2) + H(2)O.
  • The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin.
 3 G4V4T4 Q8KLK5 Q939X3
Benzalacetone synthase. [EC: 2.3.1.212]
4-coumaroyl-CoA + malonyl-CoA + H(2)O = 2 CoA + 4-hydroxybenzalacetone + 2 CO(2).
  • A polyketide synthase that catalyzes the C(6)-C(4) skeleton of phenylbutanoids in higher plants.
 2 B0LDU5 Q94FV7
2,4,6-trihydroxybenzophenone synthase. [EC: 2.3.1.220]
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO(2).
  • Involved in the biosynthesis of plant xanthones.
  • The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151).
 2 L7NCQ3 Q8SAS8
5,7-dihydroxy-2-methylchromone synthase. [EC: 2.3.1.216]
5 malonyl-CoA = 5 CoA + 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO(2) + H(2)O.
  • A polyketide synthase from the plant Aloe arborescens (aloe).
 1 Q58VP7
2,3',4,6-tetrahydroxybenzophenone synthase. [EC: 2.3.1.151]
3 malonyl-CoA + 3-hydroxybenzoyl-CoA = 4 CoA + 2,3',4,6- tetrahydroxybenzophenone + 3 CO(2).
  • Involved in the biosynthesis of plant xanthones.
  • Benzoyl-CoA can replace 3-hydroxybenzoyl-CoA (cf. EC 2.3.1.220).
 1 Q8SAS8
Phenylpropanoylacetyl-CoA synthase. [EC: 2.3.1.218]
(1) Feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO(2) + CoA. (2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO(2) + CoA.
  • The enzyme has been characterized from the plant Curcuma longa (turmeric).
  • It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA.
 1 C0SVZ5