The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dihydrofolate Reductase, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Rib7p

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase. [EC: 1.1.1.302]
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)(+) = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.
  • The reaction proceeds in the opposite direction.
  • A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant.
  • Differs from EC 1.1.1.193 since it does not catalyze the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate.
11 A0A0W0CZK9 A0A0W0CZK9 N1PAT9 N1PAT9 O66747 P33312 P33312 Q58085 Q6FU96 Q6FU96
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