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CATH Superfamily 3.40.390.10

Collagenase (Catalytic Domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Collagenase (Catalytic Domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Thimet oligopeptidase 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Neurolysin. [EC: 3.4.24.16]
Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.
  • No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do.
  • Belongs to peptidase family M3.
 7 A2VDQ5 P42675 P42676 Q02038 Q5R9V6 Q91YP2 Q9BYT8
Thimet oligopeptidase. [EC: 3.4.24.15]
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.
  • Thiol compounds activate at low concentrations.
  • Belongs to peptidase family M3.
  • Formerly EC 3.4.22.19 and EC 3.4.99.31.
 5 P24155 P47788 P52888 Q1JPJ8 Q8C1A5
Saccharolysin. [EC: 3.4.24.37]
Cleavage of Pro-|-Phe and Ala-|-Ala bonds.
  • Belongs to peptidase family M3.
  • Formerly EC 3.4.22.22.
 1 P25375
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