The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Collagenase (Catalytic Domain)
".
FunFam 17: Disintegrin and metalloproteinase domain-containin...
There are 1 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
| EC Term | Annotations | Evidence |
|---|---|---|
|
ADAM 17 endopeptidase.
[EC: 3.4.24.86]
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
|
18 |
A0A2J8NM15
A0A2J8NM15
A0A2J8NM15
A0A2J8NM15
A0A2R9BL62
A0A2R9BL62
A0A2R9BL62
A0A2R9BL62
B2RNB2
B2RNB2 (8 more...) |
