The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Aldehyde dehydrogenase A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Succinate-semialdehyde dehydrogenase (NAD+) activity GO:0004777
Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.
8 P25553 (/ISS) P25553 (/ISS) P25553 (/ISS) P25553 (/ISS) P25553 (/ISS) P25553 (/ISS) P25553 (/ISS) P25553 (/ISS)
Lactaldehyde dehydrogenase activity GO:0008911
Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+.
8 P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA)
Succinate-semialdehyde dehydrogenase [NAD(P)+] activity GO:0009013
Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+.
8 P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
8 P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA)
Glycolaldehyde dehydrogenase activity GO:0050569
Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH.
8 P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
8 H1ZV37 (/IDA) H1ZV37 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA)
Succinate-semialdehyde dehydrogenase [NAD(P)+] activity GO:0009013
Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+.
7 Q48IL4 (/ISS) Q48IL4 (/ISS) Q48IL4 (/ISS) Q48IL4 (/ISS) Q48IL4 (/ISS) Q882E8 (/ISS) Q882E8 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
6 P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
6 P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
6 P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
6 P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
6 P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA) P96405 (/IDA)
Succinate-semialdehyde dehydrogenase (NAD+) activity GO:0004777
Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.
3 Q1JUP4 (/IDA) Q1JUP4 (/IDA) Q1JUP4 (/IDA)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620
Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
3 H8ZPX2 (/IDA) Q59702 (/IDA) Q59702 (/IDA)
2,5-dioxovalerate dehydrogenase (NADP+) activity GO:0047533
Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+.
3 Q1JUP4 (/IDA) Q1JUP4 (/IDA) Q1JUP4 (/IDA)
NADP+ binding GO:0070401
Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
3 Q1JUP4 (/IDA) Q1JUP4 (/IDA) Q1JUP4 (/IDA)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
3 Q1JUP4 (/IDA) Q1JUP4 (/IDA) Q1JUP4 (/IDA)
Geranial dehydrogenase activity GO:0034832
Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+.
2 H1ZV37 (/IDA) H1ZV37 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q6L285 (/IDA) Q9HK01 (/IDA)
Glyceraldehyde dehydrogenase (NADP) activity GO:0043796
Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+.
2 Q6L285 (/IDA) Q9HK01 (/IDA)
Glutathione-disulfide reductase activity GO:0004362
Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
1 Q38AY7 (/ISA)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
9 P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) Q9HK01 (/IDA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
8 P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA) P9WNX7 (/IDA)
Rhamnose catabolic process GO:0019301
The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose.
8 P25553 (/IMP) P25553 (/IMP) P25553 (/IMP) P25553 (/IMP) P25553 (/IMP) P25553 (/IMP) P25553 (/IMP) P25553 (/IMP)
L-fucose catabolic process GO:0042355
The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).
8 P25553 (/IEP) P25553 (/IEP) P25553 (/IEP) P25553 (/IEP) P25553 (/IEP) P25553 (/IEP) P25553 (/IEP) P25553 (/IEP)
Gamma-aminobutyric acid catabolic process GO:0009450
The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
7 Q48IL4 (/ISS) Q48IL4 (/ISS) Q48IL4 (/ISS) Q48IL4 (/ISS) Q48IL4 (/ISS) Q882E8 (/ISS) Q882E8 (/ISS)
L-arabinose catabolic process to 2-oxoglutarate GO:0019570
The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate.
3 Q1JUP4 (/IDA) Q1JUP4 (/IDA) Q1JUP4 (/IDA)
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
3 Q1JUP4 (/IDA) Q1JUP4 (/IDA) Q1JUP4 (/IDA)
Entner-Doudoroff pathway through 6-phosphogluconate GO:0009255
A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.
2 Q6L285 (/IDA) Q9HK01 (/IDA)
Monoterpenoid metabolic process GO:0016098
The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton.
2 H1ZV37 (/IDA) H1ZV37 (/IDA)
Monoterpene catabolic process GO:0043694
The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure.
2 H1ZV37 (/TAS) H1ZV37 (/TAS)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
2 H1ZV37 (/IDA) H1ZV37 (/IDA)
P-cresol catabolic process GO:1901785
The chemical reactions and pathways resulting in the breakdown of p-cresol.
2 Q59702 (/IDA) Q59702 (/IDA)
Gamma-aminobutyric acid catabolic process GO:0009450
The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
1 Q38AY7 (/ISA)
Nicotine catabolic process GO:0019608
The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine.
1 H8ZPX2 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q6L285 (/ISS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
14 P96405 (/HDA) P96405 (/HDA) P96405 (/HDA) P96405 (/HDA) P96405 (/HDA) P96405 (/HDA) P9WNX7 (/HDA) P9WNX7 (/HDA) P9WNX7 (/HDA) P9WNX7 (/HDA)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA) P25553 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q551V0 (/ISS)
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