The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Aldehyde Dehydrogenase; Chain A, domain 2
".
FunFam 5: 1-pyrroline-5-carboxylate dehydrogenase 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Proline dehydrogenase activity GO:0004657
Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
|
24 |
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(14 more) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
21 |
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(11 more) |
|
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
|
17 |
P07275 (/IDA)
P07275 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(7 more) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
15 |
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
P09546 (/IPI)
(5 more) |
|
Bacterial-type proximal promoter sequence-specific DNA binding GO:0000986
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a bacterial gene (or cistron, or operon). The proximal promoter is in cis with and relatively close to the core promoter.
|
11 |
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(1 more) |
|
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
|
11 |
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(1 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
11 |
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(1 more) |
|
Proline dehydrogenase activity GO:0004657
Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
|
11 |
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
(1 more) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
11 |
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(1 more) |
|
Proline oxidase activity GO:0051699
Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2.
|
10 | P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) |
|
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
|
7 | O74766 (/ISS) Q2GGF8 (/ISS) Q2GK50 (/ISS) Q5LP42 (/ISS) Q87VC2 (/ISS) Q87VC2 (/ISS) Q8T0Q8 (/ISS) |
|
Proline dehydrogenase activity GO:0004657
Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
|
5 | Q2GGF8 (/ISS) Q2GK50 (/ISS) Q5LP42 (/ISS) Q87VC2 (/ISS) Q87VC2 (/ISS) |
|
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
|
3 | Q38BS5 (/ISA) Q38BS5 (/ISA) Q38BS5 (/ISA) |
|
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
|
3 | Q38BS5 (/ISM) Q38BS5 (/ISM) Q38BS5 (/ISM) |
|
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
|
2 | P07275 (/IMP) P07275 (/IMP) |
|
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
|
2 | P30038 (/IDA) P30038 (/IDA) |
|
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
|
1 | Q9P8I0 (/RCA) |
|
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
|
1 | Q8CHT0 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q8CHT0 (/ISO) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Proline catabolic process to glutamate GO:0010133
The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.
|
13 |
P07275 (/IMP)
P07275 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
P09546 (/IMP)
(3 more) |
|
Proline catabolic process GO:0006562
The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
|
10 | P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) |
|
Proline transport GO:0015824
The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
10 | P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
10 | P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) |
|
Proline catabolic process GO:0006562
The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
|
5 | Q2GGF8 (/ISS) Q2GK50 (/ISS) Q5LP42 (/ISS) Q87VC2 (/ISS) Q87VC2 (/ISS) |
|
Proline catabolic process GO:0006562
The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
|
3 | Q38BS5 (/ISA) Q38BS5 (/ISA) Q38BS5 (/ISA) |
|
Proline catabolic process to glutamate GO:0010133
The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.
|
3 | Q9I5F6 (/IDA) Q9I5F6 (/IDA) Q9I5F6 (/IDA) |
|
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
|
2 | P07275 (/IDA) P07275 (/IDA) |
|
Proline metabolic process GO:0006560
The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
|
2 | Q8T3P0 (/IMP) Q9VNX4 (/IMP) |
|
Proline metabolic process GO:0006560
The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
|
2 | Q8T3P0 (/ISS) Q9VNX4 (/ISS) |
|
Proline metabolic process GO:0006560
The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
Proline catabolic process GO:0006562
The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
|
2 | Q8T3P0 (/IMP) Q9VNX4 (/IMP) |
|
4-hydroxyproline catabolic process GO:0019470
The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline.
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
Glyoxylate metabolic process GO:0046487
The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
|
1 | Q9P8I0 (/RCA) |
|
Proline catabolic process to glutamate GO:0010133
The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.
|
1 | O74766 (/ISO) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
1 | Q9P8I0 (/IEP) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
11 |
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
P09546 (/IDA)
(1 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
10 | P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) P10503 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
5 | Q38BS5 (/IDA) Q38BS5 (/IDA) Q38BS5 (/IDA) Q8T3P0 (/IDA) Q9VNX4 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q38BS5 (/IDA) Q38BS5 (/IDA) Q38BS5 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q38BS5 (/IDA) Q38BS5 (/IDA) Q38BS5 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | P07275 (/HDA) P07275 (/HDA) Q8CHT0 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | Q38BS5 (/RCA) Q38BS5 (/RCA) Q38BS5 (/RCA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | P07275 (/IDA) P07275 (/IDA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | Q8T3P0 (/ISS) Q9VNX4 (/ISS) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | P30038 (/TAS) P30038 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | E9ACG7 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | E9ACG7 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | O74766 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O74766 (/HDA) |
