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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Succinate-semialdehyde dehydrogenase I

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Succinate-semialdehyde dehydrogenase (NADP(+)). [EC: 1.2.1.79]
Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH.
  • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
  • It is similar to EC 1.2.1.24 and EC 1.2.1.16 but is specific for NADP(+).
  • The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).
 160 A0A070STD3 A0A070STD3 A0A070STD3 A0A070STD3 A0A070STD3 A0A070STD3 A0A070STD3 A0A070STD3 A0A070STD3 A0A070STD3
(150 more...)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]
Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H.
    		 83 A0A0L8VVD7 A0A0L8VVD7 A0A0L8VVD7 A0A0L8VVD7 A0A0L8VVD7 A0A0L8VVD7 A0A0L8VVD7 A0A0L8VVD7 A0A0L8VVD7 A6ZKV3
    (73 more...)
    Succinate-semialdehyde dehydrogenase (NAD(+)). [EC: 1.2.1.24]
    Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.
    • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
    • It is similar to EC 1.2.1.79 and EC 1.2.1.16 but is specific for NAD(+).
    		 23 A0A0E0NAJ8 A0A0E0NAJ8 A0A2D7VBK7 A0A2D7VBK7 B2RS41 B2RS41 B9F3B6 B9F3B6 P51649 P51649
    (13 more...)
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