The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Aldehyde dehydrogenase B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
14 P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA)
(4 more)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
14 P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA)
(4 more)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
5 Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS)
Fluoroacetaldehyde dehydrogenase activity GO:0033723
Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+.
1 F8JX40 (/IDA)
Long-chain-aldehyde dehydrogenase activity GO:0050061
Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons.
1 Q9FDS1 (/IDA)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
14 P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP)
(4 more)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
14 P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA)
(4 more)
Negative regulation by symbiont of host immune response GO:0052562
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.
9 P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
5 Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 F8JX40 (/IDA) Q9FDS1 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA)
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