The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 85: Selenoprotein T

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
10 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) P62342 (/ISS) P62342 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS) Q9VMV6 (/ISS) Q9VMV6 (/ISS)
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
2 Q1H5H1 (/IDA) Q1H5H1 (/IDA)
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
2 P62342 (/ISO) P62342 (/ISO)
Selenium binding GO:0008430
Interacting selectively and non-covalently with selenium (Se).
1 P62341 (/NAS)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) P62342 (/ISS) P62342 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) Q1H5H1 (/ISS) Q1H5H1 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) Q1H5H1 (/ISS) Q1H5H1 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Insulin secretion involved in cellular response to glucose stimulus GO:0035773
The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) Q1H5H1 (/ISS) Q1H5H1 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) Q1H5H1 (/ISS) Q1H5H1 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Positive regulation of growth hormone secretion GO:0060124
Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) P62342 (/ISS) P62342 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) P62342 (/ISS) P62342 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
7 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) Q1H5H1 (/ISS) Q1H5H1 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 Q1H5H1 (/IMP) Q1H5H1 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 P62342 (/ISO) P62342 (/ISO)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 P62342 (/IMP) P62342 (/IMP)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
2 P62342 (/IMP) P62342 (/IMP)
Insulin secretion involved in cellular response to glucose stimulus GO:0035773
The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.
2 P62342 (/IMP) P62342 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 P62342 (/IMP) P62342 (/IMP)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
2 P62342 (/IMP) P62342 (/IMP)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
2 P62342 (/ISO) P62342 (/ISO)
Positive regulation of growth hormone secretion GO:0060124
Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
2 Q1H5H1 (/IMP) Q1H5H1 (/IMP)
Positive regulation of growth hormone secretion GO:0060124
Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
2 P62342 (/ISO) P62342 (/ISO)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
2 Q1H5H1 (/IDA) Q1H5H1 (/IDA)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
2 P62342 (/ISO) P62342 (/ISO)
Selenocysteine incorporation GO:0001514
The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.
1 P62341 (/NAS)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
1 P62341 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
8 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) P62342 (/ISS) P62342 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
6 A6QP01 (/ISS) A6QP01 (/ISS) A6QP01 (/ISS) P62341 (/ISS) Q5ZJN8 (/ISS) Q6PBD1 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 P62342 (/IDA) P62342 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q1H5H1 (/IDA) Q1H5H1 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 P62342 (/ISO) P62342 (/ISO)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
2 Q9VMV6 (/HDA) Q9VMV6 (/HDA)
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