The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 74: endoplasmic reticulum resident protein 44

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q9BS26 (/IPI) Q9BS26 (/IPI) Q9BS26 (/IPI) Q9BS26 (/IPI) Q9BS26 (/IPI) Q9D1Q6 (/IPI)
Protein disulfide isomerase activity GO:0003756
Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Protein disulfide isomerase activity GO:0003756
Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
3 Q7ZTP5 (/ISS) Q9D1Q6 (/ISS) Q9VI96 (/ISS)
Protein disulfide isomerase activity GO:0003756
Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
1 Q9D1Q6 (/ISO)
Peptide disulfide oxidoreductase activity GO:0015037
Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds.
1 Q9VI96 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Glycoprotein metabolic process GO:0009100
The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
5 Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
5 Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
3 Q7ZTP5 (/ISS) Q9D1Q6 (/ISS) Q9VI96 (/ISS)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
2 Q7ZTP5 (/ISS) Q9D1Q6 (/ISS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 Q6NY22 (/IMP) Q6P3G9 (/IMP)
Glycoprotein metabolic process GO:0009100
The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
2 Q7ZTP5 (/ISS) Q9D1Q6 (/ISS)
Regulation of cardiac muscle contraction by calcium ion signaling GO:0010882
Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.
2 Q6NY22 (/IMP) Q6P3G9 (/IMP)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2 Q7ZTP5 (/ISS) Q9D1Q6 (/ISS)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 Q9D1Q6 (/ISO)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
1 Q9D1Q6 (/ISO)
Glycoprotein metabolic process GO:0009100
The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
1 Q9D1Q6 (/ISO)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
1 Q9D1Q6 (/ISO)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
6 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9D1Q6 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
5 Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA) Q9BS26 (/IDA)
Specific granule lumen GO:0035580
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
5 Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS) Q9BS26 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 Q9BS26 (/HDA) Q9BS26 (/HDA) Q9BS26 (/HDA) Q9BS26 (/HDA) Q9BS26 (/HDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
2 Q7ZTP5 (/ISS) Q9D1Q6 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q7ZTP5 (/ISS) Q9D1Q6 (/ISS)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
2 Q95TL8 (/HDA) Q9VXI3 (/HDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9VI96 (/ISS)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
1 Q9D1Q6 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q9D1Q6 (/ISO)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
1 Q9D1Q6 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9D1Q6 (/ISO)
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