The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Glutaredoxin 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q86SX6 (/IPI) Q86SX6 (/IPI) Q86SX6 (/IPI) Q86SX6 (/IPI) Q8LBK6 (/IPI) Q8LBK6 (/IPI) Q9HDW8 (/IPI)
Disulfide oxidoreductase activity GO:0015036
Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
4 Q02784 (/IDA) Q02784 (/IDA) Q02784 (/IDA) Q02784 (/IDA)
Disulfide oxidoreductase activity GO:0015036
Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
4 Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
2 Q8LBK6 (/IDA) Q8LBK6 (/IDA)
Protein disulfide oxidoreductase activity GO:0015035
Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
1 Q9HDW8 (/ISS)
Glutathione disulfide oxidoreductase activity GO:0015038
Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
1 Q9HDW8 (/IMP)
Antiporter activity GO:0015297
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
1 Q84Y95 (/IDA)
Iron-sulfur transferase activity GO:0036455
Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor).
1 Q9HDW8 (/ISS)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
1 Q9HDW8 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
5 Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP) Q6PBM1 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
5 Q80Y14 (/ISS) Q86SX6 (/ISS) Q86SX6 (/ISS) Q86SX6 (/ISS) Q86SX6 (/ISS)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
4 Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP)
Protein lipoylation GO:0009249
The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.
4 Q86SX6 (/IMP) Q86SX6 (/IMP) Q86SX6 (/IMP) Q86SX6 (/IMP)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
4 Q02784 (/IGI) Q02784 (/IGI) Q02784 (/IGI) Q02784 (/IGI)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
4 Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP) Q02784 (/IMP)
Small molecule metabolic process GO:0044281
The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
4 Q86SX6 (/TAS) Q86SX6 (/TAS) Q86SX6 (/TAS) Q86SX6 (/TAS)
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q84Y95 (/IDA) Q8H7F6 (/IDA) Q8H7F6 (/IDA)
Protein lipoylation GO:0009249
The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.
1 Q80Y14 (/ISO)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q6PBM1 (/IMP)
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
1 Q9HDW8 (/IGI)
[4Fe-4S] cluster assembly GO:0044572
The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster.
1 Q9HDW8 (/ISS)
Protein maturation by [2Fe-2S] cluster transfer GO:0106034
The transfer of an assembled
1 Q9HDW8 (/IPI)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 Q6PBM1 (/IDA) Q80Y14 (/IDA) Q86SX6 (/IDA) Q86SX6 (/IDA) Q86SX6 (/IDA) Q86SX6 (/IDA) Q8LBK6 (/IDA) Q8LBK6 (/IDA) Q9HDW8 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
8 Q02784 (/IDA) Q02784 (/IDA) Q02784 (/IDA) Q02784 (/IDA) Q86SX6 (/IDA) Q86SX6 (/IDA) Q86SX6 (/IDA) Q86SX6 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 Q02784 (/HDA) Q02784 (/HDA) Q02784 (/HDA) Q02784 (/HDA) Q80Y14 (/HDA) Q9HDW8 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 Q80Y14 (/ISS) Q86SX6 (/ISS) Q86SX6 (/ISS) Q86SX6 (/ISS) Q86SX6 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 Q86SX6 (/TAS) Q86SX6 (/TAS) Q86SX6 (/TAS) Q86SX6 (/TAS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 Q84Y95 (/IDA) Q8H7F6 (/IDA) Q8H7F6 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
3 Q84Y95 (/IDA) Q8H7F6 (/IDA) Q8H7F6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 D4ADD7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q80Y14 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q6PBM1 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q80Y14 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q80Y14 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9HDW8 (/ISS)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 Q84Y95 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 D4ADD7 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q80Y14 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 D4ADD7 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q80Y14 (/ISO)
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