The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 214: glutaredoxin-1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione disulfide oxidoreductase activity GO:0015038
Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
7 P35754 (/EXP) P35754 (/EXP) P35754 (/EXP) P35754 (/EXP) P35754 (/EXP) P35754 (/EXP) P35754 (/EXP)
Glutathione disulfide oxidoreductase activity GO:0015038
Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
7 P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
7 P35754 (/IPI) P35754 (/IPI) P35754 (/IPI) P35754 (/IPI) P35754 (/IPI) P35754 (/IPI) P35754 (/IPI)
Glutathione oxidoreductase activity GO:0097573
Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione.
7 P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS)
Glutathione disulfide oxidoreductase activity GO:0015038
Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Protein-disulfide reductase (glutathione) activity GO:0019153
Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol.
2 Q9QUH0 (/TAS) Q9QUH0 (/TAS)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Glutathione disulfide oxidoreductase activity GO:0015038
Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
1 Q9ESH6 (/IDA)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 P12864 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleobase-containing small molecule interconversion GO:0015949
The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.
7 P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS)
Positive regulation of membrane potential GO:0045838
Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
7 P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA)
Protein deglutathionylation GO:0080058
The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage.
7 P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS)
Positive regulation of sodium ion transmembrane transporter activity GO:2000651
Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.
7 P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA) P35754 (/IDA)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Positive regulation of membrane potential GO:0045838
Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Positive regulation of cell adhesion molecule production GO:0060355
Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587
Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Positive regulation of sodium ion transmembrane transporter activity GO:2000651
Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 Q9ESH6 (/IEP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q9ESH6 (/IEP)
Ovulation cycle process GO:0022602
A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
1 Q9ESH6 (/IEP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 Q9ESH6 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
1 Q9ESH6 (/IMP)
Positive regulation of cell adhesion molecule production GO:0060355
Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.
1 Q9ESH6 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q9ESH6 (/IEP)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q9ESH6 (/IDA)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q9ESH6 (/IMP)
Negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
1 Q9ESH6 (/IMP)
Negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587
Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.
1 Q9ESH6 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS) P35754 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
7 P35754 (/HDA) P35754 (/HDA) P35754 (/HDA) P35754 (/HDA) P35754 (/HDA) P35754 (/HDA) P35754 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9ESH6 (/IDA) Q9QUH0 (/IDA) Q9QUH0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9ESH6 (/IDA) Q9QUH0 (/IDA) Q9QUH0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9QUH0 (/HDA) Q9QUH0 (/HDA)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q9QUH0 (/ISO) Q9QUH0 (/ISO)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
1 Q9ESH6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9ESH6 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q9ESH6 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9ESH6 (/IDA)
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