The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Glutathione S-transferase F2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
15 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42760 (/IDA) P42760 (/IDA) P42761 (/IDA) P42761 (/IDA) P46420 (/IDA) P46420 (/IDA) P46420 (/IDA)
(5 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
13 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P04907 (/IDA) P12653 (/IDA) P46420 (/IDA) P46420 (/IDA) P46420 (/IDA) P46422 (/IDA) P46422 (/IDA)
(3 more)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
9 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42760 (/IDA) P42760 (/IDA) P42761 (/IDA) P42761 (/IDA) Q9SRY5 (/IDA) Q9SRY5 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P46420 (/IDA) P46420 (/IDA) P46420 (/IDA) Q9SM20 (/IDA) Q9ZP62 (/IDA)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
4 P42760 (/IDA) P42760 (/IDA) Q9SRY5 (/IDA) Q9SRY5 (/IDA)
Camalexin binding GO:2001147
Interacting selectively and non-covalently with camalexin.
4 P42760 (/IDA) P42760 (/IDA) P46422 (/IDA) P46422 (/IDA)
Quercitrin binding GO:2001227
Interacting selectively and non-covalently with quercitrin.
4 P42760 (/IDA) P42760 (/IDA) P46422 (/IDA) P46422 (/IDA)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
3 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 P46422 (/IPI) P46422 (/IPI)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 Q96266 (/ISS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 Q9ZP62 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P04907 (/NAS)
Cation binding GO:0043169
Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.
1 Q9FE46 (/IDA)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Toxin catabolic process GO:0009407
The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
18 O80852 (/TAS) O80852 (/TAS) O80852 (/TAS) P42760 (/TAS) P42760 (/TAS) P42761 (/TAS) P42761 (/TAS) P46422 (/TAS) P46422 (/TAS) Q84TK0 (/TAS)
(8 more)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
11 O80852 (/IEP) O80852 (/IEP) O80852 (/IEP) P42760 (/IEP) P42760 (/IEP) P42761 (/IEP) P42761 (/IEP) P46422 (/IEP) P46422 (/IEP) Q9SRY5 (/IEP)
(1 more)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
10 O80852 (/IEP) O80852 (/IEP) O80852 (/IEP) P42760 (/IEP) P42760 (/IEP) P46422 (/IEP) P46422 (/IEP) Q96266 (/IEP) Q9SRY5 (/IEP) Q9SRY5 (/IEP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
7 P42760 (/IEP) P42760 (/IEP) P46422 (/IEP) P46422 (/IEP) Q96266 (/IEP) Q9SRY5 (/IEP) Q9SRY5 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
6 P04907 (/IDA) P46420 (/IDA) P46420 (/IDA) P46420 (/IDA) Q9SM20 (/IDA) Q9ZP62 (/IDA)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
5 O80852 (/IEP) O80852 (/IEP) O80852 (/IEP) P46422 (/IEP) P46422 (/IEP)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
4 O80852 (/IEP) O80852 (/IEP) O80852 (/IEP) Q96266 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
4 P42760 (/IEP) P42760 (/IEP) P42761 (/IEP) P42761 (/IEP)
Response to oomycetes GO:0002239
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes.
3 P46422 (/IEP) P46422 (/IEP) Q9SLM6 (/IEP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
3 P42760 (/IEP) P42760 (/IEP) Q96324 (/IEP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
3 P46422 (/IEP) P46422 (/IEP) Q96266 (/IEP)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
3 P46420 (/IDA) P46420 (/IDA) P46420 (/IDA)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 P42760 (/IDA) P42760 (/IDA)
Defense response to fungus, incompatible interaction GO:0009817
A response of an organism to a fungus that prevents the occurrence or spread of disease.
2 Q9SRY5 (/IDA) Q9SRY5 (/IDA)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 P12653 (/IEP)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 P12653 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 P12653 (/TAS)
Response to salicylic acid GO:0009751
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.
1 P12653 (/TAS)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P12653 (/TAS)
Anthocyanin-containing compound metabolic process GO:0046283
The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers.
1 Q9FE46 (/IMP)
Response to karrikin GO:0080167
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants).
1 Q96266 (/IEP)
Regulation of flavonol biosynthetic process GO:1900384
Any process that modulates the frequency, rate or extent of flavonol biosynthetic process.
1 Q9FE46 (/IMP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
15 O80852 (/NAS) O80852 (/NAS) O80852 (/NAS) P42760 (/NAS) P42760 (/NAS) P42761 (/NAS) P42761 (/NAS) Q84TK0 (/NAS) Q96324 (/NAS) Q9FE46 (/NAS)
(5 more)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
11 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42760 (/IDA) P42760 (/IDA) P42761 (/IDA) P42761 (/IDA) P46422 (/IDA) P46422 (/IDA) Q9SRY5 (/IDA)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42760 (/IDA) P42760 (/IDA) P42761 (/IDA) P42761 (/IDA) P46422 (/IDA) P46422 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42761 (/IDA) P42761 (/IDA) P46422 (/IDA) P46422 (/IDA) Q9SLM6 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
8 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42761 (/IDA) P42761 (/IDA) P46422 (/IDA) P46422 (/IDA) Q96266 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
7 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42760 (/IDA) P42760 (/IDA) P46422 (/IDA) P46422 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
7 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P42761 (/IDA) P42761 (/IDA) P46422 (/IDA) P46422 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
6 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) P46422 (/IDA) P46422 (/IDA) Q96266 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
6 P12653 (/IDA) P46420 (/IDA) P46420 (/IDA) P46420 (/IDA) Q9SM20 (/IDA) Q9ZP62 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
4 P42760 (/IDA) P42760 (/IDA) P42761 (/IDA) P42761 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q96266 (/IDA) Q9FE46 (/IDA) Q9SRY5 (/IDA) Q9SRY5 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
4 O80852 (/IDA) O80852 (/IDA) O80852 (/IDA) Q96266 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9FE46 (/IDA) Q9SRY5 (/IDA) Q9SRY5 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P42760 (/IDA) P42760 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P46422 (/IDA) P46422 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 P46422 (/IDA) P46422 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 Q96266 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q96266 (/ISS)
Plant-type vacuole membrane GO:0009705
The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
1 Q9FE46 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 Q96266 (/IDA)
Stromule GO:0010319
Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types.
1 Q96266 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P04907 (/NAS)
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