The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Glutaredoxin
".
FunFam 156: Glutathione S-transferase 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
|
9 | A0A1D8PJR2 (/IDA) A0A1D8PJR2 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) Q9P6M1 (/IDA) |
|
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
|
6 | P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) |
|
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
|
1 | Q9P6M1 (/IMP) |
|
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
|
1 | Q9P6M1 (/IMP) |
There are 3 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
|
6 | P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) |
|
Protein glutathionylation GO:0010731
The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.
|
6 | P40582 (/IMP) P40582 (/IMP) P40582 (/IMP) P40582 (/IMP) P40582 (/IMP) P40582 (/IMP) |
|
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
|
1 | Q9P6M1 (/NAS) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
8 | A0A1D8PJR2 (/IDA) A0A1D8PJR2 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) P40582 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
7 | P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) Q9P6M1 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
6 | P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) |
|
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
6 | P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) |
|
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
6 | P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) P40582 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9P6M1 (/IDA) |
