The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Glutaredoxin
".
FunFam 140: polyglutamine-binding protein 1 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
11 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
Q6PCT5 (/ISS)
Q91VJ5 (/ISS)
(1 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | O60828 (/IPI) O60828 (/IPI) O60828 (/IPI) O60828 (/IPI) O60828 (/IPI) Q6PCT5 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
5 | O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
5 | O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
5 | O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) |
|
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
5 | O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q6PCT5 (/IPI) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
14 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
O60828 (/ISS)
O60828 (/ISS)
(4 more) |
|
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
|
11 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
Q6PCT5 (/ISS)
Q91VJ5 (/ISS)
(1 more) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
11 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
Q6PCT5 (/ISS)
Q91VJ5 (/ISS)
(1 more) |
|
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
11 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
Q6PCT5 (/ISS)
Q91VJ5 (/ISS)
(1 more) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
11 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
Q6PCT5 (/ISS)
Q91VJ5 (/ISS)
(1 more) |
|
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
11 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
Q6PCT5 (/ISS)
Q91VJ5 (/ISS)
(1 more) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
9 | A1YFA7 (/ISS) A1YFA7 (/ISS) A1YFA7 (/ISS) A1YFA7 (/ISS) A1YFA7 (/ISS) A2T806 (/ISS) A2T806 (/ISS) A2T806 (/ISS) Q6PCT5 (/ISS) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
7 | O60828 (/IMP) O60828 (/IMP) O60828 (/IMP) O60828 (/IMP) O60828 (/IMP) Q91VJ5 (/IMP) Q91VJ5 (/IMP) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
5 | O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) |
|
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
|
5 | O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
5 | O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) |
|
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
5 | O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
5 | O60828 (/IMP) O60828 (/IMP) O60828 (/IMP) O60828 (/IMP) O60828 (/IMP) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
5 | O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
5 | O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | Q91VJ5 (/IMP) Q91VJ5 (/IMP) |
|
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
|
2 | Q91VJ5 (/IMP) Q91VJ5 (/IMP) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Positive regulation of non-motile cilium assembly GO:1902857
Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
|
1 | O16786 (/IMP) |
|
Positive regulation of non-motile cilium assembly GO:1902857
Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly.
|
1 | Q6PCT5 (/IMP) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
14 |
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A1YFA7 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
A2T806 (/ISS)
O60828 (/ISS)
O60828 (/ISS)
(4 more) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
12 |
A0A0S2Z4V5 (/IDA)
A0A0S2Z4V5 (/IDA)
A0A0S2Z4V5 (/IDA)
A0A0S2Z4V5 (/IDA)
A0A0S2Z4V5 (/IDA)
O60828 (/IDA)
O60828 (/IDA)
O60828 (/IDA)
O60828 (/IDA)
O60828 (/IDA)
(2 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | A0A0S2Z4V5 (/IDA) A0A0S2Z4V5 (/IDA) A0A0S2Z4V5 (/IDA) A0A0S2Z4V5 (/IDA) A0A0S2Z4V5 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) O60828 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) O60828 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q6PCT5 (/IDA) Q91VJ5 (/IDA) Q91VJ5 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q91VJ5 (/IDA) Q91VJ5 (/IDA) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
2 | Q91VJ5 (/IDA) Q91VJ5 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Neuronal ribonucleoprotein granule GO:0071598
A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.
|
2 | Q91VJ5 (/IDA) Q91VJ5 (/IDA) |
|
Ciliary base GO:0097546
Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
|
2 | Q91VJ5 (/ISO) Q91VJ5 (/ISO) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q6PCT5 (/IDA) |
|
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
1 | Q6PCT5 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | O16786 (/IDA) |
|
Ciliary base GO:0097546
Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
|
1 | Q6PCT5 (/IDA) |
