The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 123: Glutathione transferase o1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
7 P34345 (/IDA) Q7K206 (/IDA) Q9VSL2 (/IDA) Q9VSL3 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA) Q9VSL6 (/IDA)
Glutathione dehydrogenase (ascorbate) activity GO:0045174
Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
7 P34345 (/IDA) Q7K206 (/IDA) Q9VSL2 (/IDA) Q9VSL3 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA) Q9VSL6 (/IDA)
Transferase activity, transferring sulfur-containing groups GO:0016782
Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor).
6 Q7K206 (/IDA) Q9VSL2 (/IDA) Q9VSL3 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA) Q9VSL6 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q7K206 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
3 Q7K206 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA)
Pyrimidodiazepine synthase activity GO:0004734
Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione.
1 Q9VSL3 (/IDA)
Pyrimidodiazepine synthase activity GO:0004734
Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione.
1 Q9VSL3 (/IGI)
Pyrimidodiazepine synthase activity GO:0004734
Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione.
1 Q9VSL3 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9VSL3 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
6 Q7K206 (/IDA) Q9VSL2 (/IDA) Q9VSL3 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA) Q9VSL6 (/IDA)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
3 Q7K206 (/HMP) Q9VSL4 (/HMP) Q9VSL5 (/HMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
3 Q7K206 (/HMP) Q9VSL4 (/HMP) Q9VSL5 (/HMP)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 O45352 (/IMP)
Response to superoxide GO:0000303
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
1 P34345 (/IMP)
Eye pigment biosynthetic process GO:0006726
The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.
1 Q9VSL3 (/IGI)
Pteridine biosynthetic process GO:0006728
The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.
1 Q9VSL3 (/IDA)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P34345 (/IDA)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P34345 (/IMP)
Protein glutathionylation GO:0010731
The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.
1 P34345 (/IDA)
Cellular response to extracellular stimulus GO:0031668
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
1 P34345 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P34345 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 Q7K206 (/ISS) Q9VSL2 (/ISS) Q9VSL3 (/ISS) Q9VSL4 (/ISS) Q9VSL5 (/ISS) Q9VSL6 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q7K206 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q7K206 (/IDA) Q9VSL4 (/IDA) Q9VSL5 (/IDA)
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