The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Glutaredoxin
".
FunFam 12: Monothiol glutaredoxin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
O74790 (/IPI)
O76003 (/IPI)
O76003 (/IPI)
P32642 (/IPI)
P32642 (/IPI)
Q03835 (/IPI)
Q9CQM9 (/IPI)
Q9VJZ6 (/IPI)
Q9ZPH2 (/IPI)
Q9ZPH2 (/IPI)
(1 more) |
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
3 | P32642 (/IPI) P32642 (/IPI) Q03835 (/IPI) |
Disulfide oxidoreductase activity GO:0015036
Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
|
3 | P32642 (/IMP) P32642 (/IMP) Q03835 (/IMP) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | O76003 (/HDA) O76003 (/HDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | O76003 (/IPI) O76003 (/IPI) |
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
1 | Q9JLZ1 (/IDA) |
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
1 | Q9CQM9 (/ISO) |
Glutathione disulfide oxidoreductase activity GO:0015038
Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
|
1 | O74790 (/IMP) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9CQM9 (/ISO) |
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
1 | O74790 (/IDA) |
Protein sequestering activity GO:0140311
The selective interaction of a protein with a specific protein, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell.
|
1 | O74790 (/EXP) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
|
4 | O74790 (/IGI) P32642 (/IGI) P32642 (/IGI) Q03835 (/IGI) |
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
|
3 | O76003 (/ISS) O76003 (/ISS) Q58DA7 (/ISS) |
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
|
3 | P32642 (/IPI) P32642 (/IPI) Q03835 (/IPI) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
3 | Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
3 | Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) |
Auxin polar transport GO:0009926
The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally.
|
3 | Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) |
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
3 | O76003 (/ISS) O76003 (/ISS) Q58DA7 (/ISS) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
3 | P32642 (/IMP) P32642 (/IMP) Q03835 (/IMP) |
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
|
3 | P32642 (/IMP) P32642 (/IMP) Q03835 (/IMP) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
3 | P32642 (/IMP) P32642 (/IMP) Q03835 (/IMP) |
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
|
3 | Q28ID3 (/ISS) Q9CQM9 (/ISS) Q9JLZ1 (/ISS) |
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
3 | Q9ZPH2 (/IEP) Q9ZPH2 (/IEP) Q9ZPH2 (/IEP) |
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
|
3 | Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) Q9ZPH2 (/IMP) |
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
|
3 | Q28ID3 (/ISS) Q9CQM9 (/ISS) Q9JLZ1 (/ISS) |
Negative regulation of transcription regulatory region DNA binding GO:2000678
Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
|
3 | P32642 (/IMP) P32642 (/IMP) Q03835 (/IMP) |
Hemoglobin metabolic process GO:0020027
The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
|
2 | Q5XJ54 (/IGI) Q5XJ54 (/IGI) |
Hemoglobin metabolic process GO:0020027
The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
|
2 | Q5XJ54 (/IMP) Q5XJ54 (/IMP) |
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
|
2 | O76003 (/IDA) O76003 (/IDA) |
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
|
2 | Q5XJ54 (/IMP) Q5XJ54 (/IMP) |
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
|
2 | O76003 (/IDA) O76003 (/IDA) |
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
|
1 | Q9CQM9 (/IMP) |
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
|
1 | O74790 (/IMP) |
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
1 | Q9CQM9 (/IMP) |
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
|
1 | Q9CQM9 (/ISO) |
[4Fe-4S] cluster assembly GO:0044572
The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster.
|
1 | O74790 (/ISO) |
Protein maturation GO:0051604
Any process leading to the attainment of the full functional capacity of a protein.
|
1 | O74790 (/ISO) |
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
|
1 | Q9CQM9 (/ISO) |
Negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903026
Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
|
1 | O74790 (/IMP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O74790 (/IDA) P32642 (/IDA) P32642 (/IDA) Q03835 (/IDA) Q9JLZ1 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | O74790 (/IDA) Q03835 (/IDA) Q9ZPH2 (/IDA) Q9ZPH2 (/IDA) Q9ZPH2 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | H2KZJ5 (/HDA) H2KZJ5 (/HDA) Q6EZG4 (/HDA) |
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
|
3 | H2KZJ5 (/HDA) H2KZJ5 (/HDA) Q6EZG4 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O74790 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9CQM9 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O74790 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O74790 (/HDA) |
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | Q9CQM9 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q9JLZ1 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q9CQM9 (/ISO) |