The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Glutathione peroxidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
31 P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA)
(21 more)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
22 P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P38143 (/IMP) P38143 (/IMP) P38143 (/IMP) P38143 (/IMP)
(12 more)
Phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066
Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.
22 P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA)
(12 more)
Phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066
Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.
22 P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P38143 (/IMP) P38143 (/IMP) P38143 (/IMP) P38143 (/IMP)
(12 more)
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
16 O59858 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA)
(6 more)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
5 Q60AL0 (/ISS) Q8EGN7 (/ISS) Q8IRD3 (/ISS) Q8IRD4 (/ISS) Q9VZQ8 (/ISS)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
3 Q8IRD3 (/IDA) Q8IRD4 (/IDA) Q9VZQ8 (/IDA)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
1 C8VJD9 (/RCA)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
24 P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P38143 (/IMP) P38143 (/IMP) P38143 (/IMP) P38143 (/IMP)
(14 more)
Response to hydroperoxide GO:0033194
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
15 P06610 (/IEP) P06610 (/IEP) P06610 (/IEP) P06610 (/IEP) P06610 (/IEP) P06610 (/IEP) P06610 (/IEP) P06610 (/IEP) P06610 (/IEP) P06610 (/IEP)
(5 more)
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
6 P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP) P36014 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
3 Q8IRD3 (/IMP) Q8IRD4 (/IMP) Q9VZQ8 (/IMP)
Response to lipid hydroperoxide GO:0006982
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids.
3 Q8IRD3 (/ISS) Q8IRD4 (/ISS) Q9VZQ8 (/ISS)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
2 Q60AL0 (/ISS) Q8EGN7 (/ISS)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
2 Q60AL0 (/ISS) Q8EGN7 (/ISS)
Peptidyl-cysteine oxidation GO:0018171
The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid.
2 Q59WD3 (/IMP) Q59WD3 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide GO:0061407
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus.
2 Q59WD3 (/IMP) Q59WD3 (/IMP)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
1 C8VJD9 (/RCA)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 C8VJD9 (/IEP)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
1 Q8IRD3 (/IMP)
Intestinal stem cell homeostasis GO:0036335
Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.
1 Q8IRD3 (/IMP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
1 O59858 (/IDA)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
1 O59858 (/IMP)
Cellular detoxification of hydrogen peroxide GO:0061692
Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration.
1 O59858 (/IDA)
Cellular response to farnesol GO:0097308
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.
1 C8VJD9 (/IEP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
17 O59858 (/HDA) P36014 (/HDA) P36014 (/HDA) P36014 (/HDA) P36014 (/HDA) P36014 (/HDA) P36014 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA)
(7 more)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
16 P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA)
(6 more)
Periplasmic space GO:0042597
The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
15 P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA) P06610 (/IDA)
(5 more)
Extrinsic component of mitochondrial outer membrane GO:0031315
The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
12 P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P36014 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 P40581 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA) P40581 (/HDA)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
10 P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA) P40581 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 O59858 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 O59858 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA) P38143 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA)
Extrinsic component of mitochondrial inner membrane GO:0031314
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
6 P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA) P38143 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q8IRD3 (/ISS) Q8IRD4 (/ISS) Q9VZQ8 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q8IRD3 (/ISS) Q8IRD4 (/ISS) Q9VZQ8 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
3 Q8IRD3 (/IDA) Q8IRD4 (/IDA) Q9VZQ8 (/IDA)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
3 Q8IRD3 (/HDA) Q8IRD4 (/HDA) Q9VZQ8 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 H2KYJ6 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O59858 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O59858 (/IDA)
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