The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodanese-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Dual specificity protein phosphatase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017
Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.
12 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
(2 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS) Q91790 (/ISS) Q91790 (/ISS)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
6 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) Q64623 (/ISS)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
5 P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
5 Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS) Q91790 (/ISS) Q91790 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P28562 (/IPI) P28562 (/IPI) P28562 (/IPI) P28562 (/IPI) P28562 (/IPI)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
5 P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA)
MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017
Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.
4 P28563 (/IMP) P28563 (/IMP) Q91790 (/IMP) Q91790 (/IMP)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
2 P28563 (/IMP) P28563 (/IMP)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2 P28563 (/IMP) P28563 (/IMP)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2 P28563 (/ISO) P28563 (/ISO)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2 P28563 (/ISO) P28563 (/ISO)
Protein tyrosine/threonine phosphatase activity GO:0008330
Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2 P28563 (/ISO) P28563 (/ISO)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
2 P28563 (/ISO) P28563 (/ISO)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
2 P28563 (/IDA) P28563 (/IDA)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
2 P28563 (/IPI) P28563 (/IPI)
Protein tyrosine/threonine phosphatase activity GO:0008330
Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 Q64623 (/IDA)
MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017
Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.
1 Q64623 (/TAS)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 Q64623 (/IPI)

There are 53 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
12 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
(2 more)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Negative regulation of meiotic cell cycle GO:0051447
Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Peptidyl-serine dephosphorylation GO:0070262
The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine.
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS) Q91790 (/ISS) Q91790 (/ISS)
Mitotic cell cycle arrest GO:0071850
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266
Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
10 P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28562 (/ISS) P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
7 P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) Q91790 (/IDA) Q91790 (/IDA)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
5 P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
5 P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA)
Negative regulation of monocyte chemotaxis GO:0090027
Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.
5 P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP)
Negative regulation of p38MAPK cascade GO:1903753
Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.
5 P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP)
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
5 P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP) P28562 (/IMP)
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
4 P28563 (/IMP) P28563 (/IMP) Q91790 (/IMP) Q91790 (/IMP)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
3 P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
2 Q91790 (/IMP) Q91790 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
2 P28563 (/ISO) P28563 (/ISO)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
2 P28563 (/ISO) P28563 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 P28563 (/IMP) P28563 (/IMP)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
2 P28563 (/IMP) P28563 (/IMP)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
2 P28563 (/ISO) P28563 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 P28563 (/ISO) P28563 (/ISO)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
2 Q91790 (/IDA) Q91790 (/IDA)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
2 P28563 (/IMP) P28563 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 P28563 (/ISO) P28563 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P28563 (/ISO) P28563 (/ISO)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
2 P28563 (/ISO) P28563 (/ISO)
Negative regulation of meiotic cell cycle GO:0051447
Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.
2 Q91790 (/IMP) Q91790 (/IMP)
Peptidyl-serine dephosphorylation GO:0070262
The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine.
2 P28563 (/IMP) P28563 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P28563 (/ISO) P28563 (/ISO)
Mitotic cell cycle arrest GO:0071850
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).
2 Q91790 (/IMP) Q91790 (/IMP)
Negative regulation of monocyte chemotaxis GO:0090027
Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.
2 P28563 (/ISO) P28563 (/ISO)
Regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266
Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
2 Q91790 (/IMP) Q91790 (/IMP)
Negative regulation of p38MAPK cascade GO:1903753
Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.
2 P28563 (/ISO) P28563 (/ISO)
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
2 P28563 (/ISO) P28563 (/ISO)
Negative regulation of DNA biosynthetic process GO:2000279
Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
2 P28563 (/ISO) P28563 (/ISO)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 Q64623 (/IDA)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
1 Q64623 (/IEP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 Q64623 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q64623 (/IEP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 Q64623 (/IEP)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 Q64623 (/IEP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 Q64623 (/IEP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q64623 (/IDA)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q64623 (/IEP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q64623 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q64623 (/IMP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q64623 (/IEP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q64623 (/IEP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q64623 (/IEP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q64623 (/IMP)
Negative regulation of DNA biosynthetic process GO:2000279
Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
1 Q64623 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) Q64623 (/IDA) Q91790 (/IDA) Q91790 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) P28562 (/IDA) Q91790 (/IDA) Q91790 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P28563 (/ISS) P28563 (/ISS) Q64623 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P28563 (/ISS) P28563 (/ISS) Q90W58 (/ISS) Q90W58 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P28563 (/ISO) P28563 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P28563 (/ISO) P28563 (/ISO)
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