The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Severin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Gelsolin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O88398 (/IPI) P06396 (/IPI) P06396 (/IPI) P09327 (/IPI) P10733 (/IPI) P13020 (/IPI) Q62468 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
6 P06396 (/IDA) P06396 (/IDA) Q28046 (/IDA) Q68FP1 (/IDA) Q7JQD3 (/IDA) Q9WU06 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
5 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS) Q9Y6U3 (/ISS)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
5 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS) Q9Y6U3 (/ISS)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
5 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS) Q9Y6U3 (/ISS)
Lysophosphatidic acid binding GO:0035727
Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
4 P02640 (/ISS) P09327 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
3 O75366 (/ISS) O88398 (/ISS) Q9Y6U3 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 P09327 (/IDA) Q28046 (/IDA) Q7JQD3 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 P06396 (/IMP) P06396 (/IMP) P09327 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 P06396 (/TAS) P06396 (/TAS) Q9Y6U3 (/TAS)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
3 P09327 (/IDA) P10733 (/IDA) Q28046 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 O88398 (/ISO) P13020 (/ISO)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 Q9WU06 (/TAS) Q9Y6U3 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P13020 (/ISO) Q62468 (/ISO)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
2 P09327 (/IDA) Q28046 (/IDA)
Myosin II binding GO:0045159
Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
2 P06396 (/IPI) P06396 (/IPI)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q28046 (/IDA)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q9Y6U3 (/ISS)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
1 P36418 (/IDA)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 Q9Y6U3 (/TAS)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 Q62468 (/ISO)
Lysophosphatidic acid binding GO:0035727
Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.
1 P09327 (/IDA)
Lysophosphatidic acid binding GO:0035727
Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.
1 Q62468 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P09327 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q62468 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P09327 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q62468 (/ISO)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q62468 (/IMP)
Myosin II binding GO:0045159
Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
1 P13020 (/ISO)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 P10733 (/TAS)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q62468 (/ISO)

There are 151 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
15 G1S5M3 (/ISS) G3S1L6 (/ISS) H2QXT3 (/ISS) H9Z838 (/ISS) I3M611 (/ISS) P02640 (/ISS) P13020 (/ISS) P20305 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
(5 more)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
14 G1S5M3 (/ISS) G3S1L6 (/ISS) H2QXT3 (/ISS) H9Z838 (/ISS) I3M611 (/ISS) P02640 (/ISS) P13020 (/ISS) P20305 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
(4 more)
Actin filament capping GO:0051693
The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
12 G1S5M3 (/ISS) G3S1L6 (/ISS) H2QXT3 (/ISS) H9Z838 (/ISS) I3M611 (/ISS) P02640 (/ISS) P06396 (/ISS) P06396 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
(2 more)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
9 O88398 (/ISS) O93510 (/ISS) P13020 (/ISS) P14885 (/ISS) P20305 (/ISS) Q28372 (/ISS) Q3SX14 (/ISS) Q68FP1 (/ISS) Q9WU06 (/ISS)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
8 G1S5M3 (/ISS) G3S1L6 (/ISS) H2QXT3 (/ISS) H9Z838 (/ISS) I3M611 (/ISS) P06396 (/ISS) P06396 (/ISS) U3F2N1 (/ISS)
Positive regulation of protein processing in phagocytic vesicle GO:1903923
Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle.
8 G1S5M3 (/ISS) G3S1L6 (/ISS) H2QXT3 (/ISS) H9Z838 (/ISS) I3M611 (/ISS) P06396 (/ISS) P06396 (/ISS) U3F2N1 (/ISS)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
6 P06396 (/IDA) P06396 (/IDA) P09327 (/IDA) P10733 (/IDA) Q28046 (/IDA) Q7JQD3 (/IDA)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
5 P06396 (/IDA) P06396 (/IDA) P09327 (/IDA) P13020 (/IDA) Q7JQD3 (/IDA)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
5 P06396 (/IMP) P06396 (/IMP) P13020 (/IMP) Q68FP1 (/IMP) Q9Y6U3 (/IMP)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Regulation of actin nucleation GO:0051125
Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Actin filament capping GO:0051693
The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
4 G1U9R8 (/IDA) P09327 (/IDA) P13020 (/IDA) Q7JQD3 (/IDA)
Regulation of wound healing GO:0061041
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
4 P02640 (/ISS) P09327 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Regulation of lamellipodium morphogenesis GO:2000392
Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis.
4 P02640 (/ISS) P09327 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
3 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Regulation of chondrocyte differentiation GO:0032330
Any process that modulates the frequency, rate or extent of chondrocyte differentiation.
3 Q28046 (/ISS) Q60604 (/ISS) Q9Y6U3 (/ISS)
Cellular response to hepatocyte growth factor stimulus GO:0035729
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
3 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Sequestering of actin monomers GO:0042989
The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.
3 P06396 (/IMP) P06396 (/IMP) Q9Y6U3 (/IMP)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
3 P13020 (/ISO) Q60604 (/ISO) Q62468 (/ISO)
Positive regulation of actin nucleation GO:0051127
Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
3 P06396 (/IMP) P06396 (/IMP) Q9Y6U3 (/IMP)
Actin filament capping GO:0051693
The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
3 P06396 (/IMP) P06396 (/IMP) Q9Y6U3 (/IMP)
Actin filament capping GO:0051693
The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
3 P13020 (/ISO) Q60604 (/ISO) Q62468 (/ISO)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
3 O75366 (/IMP) P06396 (/IMP) P06396 (/IMP)
Cytoplasmic actin-based contraction involved in cell motility GO:0060327
The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another.
3 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P06396 (/IMP) P06396 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 O88398 (/IDA) Q9WU06 (/IDA)
Striated muscle atrophy GO:0014891
A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
2 P06396 (/IMP) P06396 (/IMP)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
2 P06396 (/IMP) P06396 (/IMP)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
2 P13020 (/ISO) Q62468 (/ISO)
Actin filament fragmentation GO:0030043
The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins.
2 P10733 (/IDA) Q7JQD3 (/IDA)
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
2 P06396 (/IMP) P06396 (/IMP)
Sequestering of actin monomers GO:0042989
The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.
2 P13020 (/ISO) Q60604 (/ISO)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P06396 (/TAS) P06396 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
2 P06396 (/TAS) P06396 (/TAS)
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
2 Q28046 (/IDA) Q7JQD3 (/IDA)
Negative regulation of viral entry into host cell GO:0046597
Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.
2 P06396 (/IMP) P06396 (/IMP)
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
2 P06396 (/TAS) P06396 (/TAS)
Positive regulation of actin nucleation GO:0051127
Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
2 P13020 (/ISO) Q60604 (/ISO)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
2 O88398 (/ISO) P13020 (/ISO)
Regulation of podosome assembly GO:0071801
Any process that modulates the frequency, rate or extent of podosome assembly.
2 P06396 (/IMP) P06396 (/IMP)
Actin filament reorganization GO:0090527
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments.
2 P06396 (/IGI) P06396 (/IGI)
Renal protein absorption GO:0097017
A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).
2 P06396 (/IMP) P06396 (/IMP)
Hepatocyte apoptotic process GO:0097284
Any apoptotic process in a hepatocyte, the main structural component of the liver.
2 P06396 (/IMP) P06396 (/IMP)
Positive regulation of keratinocyte apoptotic process GO:1902174
Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process.
2 P06396 (/IMP) P06396 (/IMP)
Regulation of establishment of T cell polarity GO:1903903
Any process that modulates the frequency, rate or extent of establishment of T cell polarity.
2 P06396 (/IMP) P06396 (/IMP)
Regulation of plasma membrane raft polarization GO:1903906
Any process that modulates the frequency, rate or extent of plasma membrane raft polarization.
2 P06396 (/IMP) P06396 (/IMP)
Regulation of receptor clustering GO:1903909
Any process that modulates the frequency, rate or extent of receptor clustering.
2 P06396 (/IMP) P06396 (/IMP)
Amyloid fibril formation GO:1990000
The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
2 P06396 (/IMP) P06396 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001269
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.
2 P06396 (/IMP) P06396 (/IMP)
Intestinal D-glucose absorption GO:0001951
Uptake of D-glucose into the blood by absorption from the small intestine.
1 Q62468 (/IGI)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
1 P13020 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q68FP1 (/IDA)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 P13020 (/ISO)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 O88398 (/ISS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P09327 (/IDA)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q62468 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q9WU06 (/IDA)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O88398 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O75366 (/TAS)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q68FP1 (/IEP)
Actin polymerization or depolymerization GO:0008154
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
1 Q68FP1 (/IDA)
Actin polymerization or depolymerization GO:0008154
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
1 P13020 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9Y6U3 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q60604 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q28046 (/ISS)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 P09327 (/IDA)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 Q62468 (/ISO)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P09327 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q62468 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P13020 (/ISO)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 P09327 (/IDA)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 P09327 (/IGI)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 P09327 (/IMP)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 Q62468 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O88398 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O75366 (/ISS)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
1 Q68FP1 (/IEP)
Striated muscle atrophy GO:0014891
A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
1 P13020 (/ISO)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 P13020 (/IMP)
Calcium-ion regulated exocytosis GO:0017156
The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
1 Q28046 (/IDA)
Calcium-ion regulated exocytosis GO:0017156
The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
1 Q9Y6U3 (/ISS)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
1 P09327 (/IDA)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
1 Q62468 (/ISO)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 Q68FP1 (/IMP)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 P13020 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P09327 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q62468 (/ISO)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
1 P09327 (/IMP)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
1 Q62468 (/ISO)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 P09327 (/IEP)
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
1 P13020 (/ISO)
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
1 P09327 (/IDA)
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
1 Q62468 (/ISO)
Regulation of chondrocyte differentiation GO:0032330
Any process that modulates the frequency, rate or extent of chondrocyte differentiation.
1 Q5ZIV9 (/IDA)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 Q62468 (/IGI)
Cellular response to hepatocyte growth factor stimulus GO:0035729
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
1 Q62468 (/IDA)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
1 Q62468 (/IGI)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q68FP1 (/IEP)
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
1 Q68FP1 (/IEP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q9Y6U3 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q60604 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q28046 (/ISS)
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
1 Q9Y6U3 (/ISS)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 Q68FP1 (/IEP)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
1 Q9Y6U3 (/IMP)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
1 Q60604 (/ISO)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
1 Q28046 (/ISS)
Negative regulation of viral entry into host cell GO:0046597
Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.
1 P13020 (/ISO)
Phosphatidylinositol-mediated signaling GO:0048015
A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 Q68FP1 (/IMP)
Phosphatidylinositol-mediated signaling GO:0048015
A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 P13020 (/ISO)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
1 P09327 (/TAS)
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
1 P36418 (/IDA)
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
1 P09327 (/IMP)
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
1 Q62468 (/ISO)
Positive regulation of secretion GO:0051047
Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
1 Q28046 (/IDA)
Positive regulation of secretion GO:0051047
Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
1 Q9Y6U3 (/ISS)
Regulation of actin nucleation GO:0051125
Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
1 P09327 (/IDA)
Regulation of actin nucleation GO:0051125
Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
1 Q62468 (/ISO)
Response to folic acid GO:0051593
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.
1 Q68FP1 (/IEP)
Cytoplasmic actin-based contraction involved in cell motility GO:0060327
The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another.
1 P09327 (/IDA)
Cytoplasmic actin-based contraction involved in cell motility GO:0060327
The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another.
1 Q62468 (/ISO)
Regulation of wound healing GO:0061041
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
1 Q62468 (/IDA)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
1 P09327 (/TAS)
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q68FP1 (/IDA)
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 P13020 (/ISO)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 P13020 (/IDA)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 P09327 (/IDA)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 Q62468 (/ISO)
Regulation of podosome assembly GO:0071801
Any process that modulates the frequency, rate or extent of podosome assembly.
1 P13020 (/ISO)
Actin filament reorganization GO:0090527
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments.
1 P13020 (/ISO)
Renal protein absorption GO:0097017
A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).
1 P13020 (/ISO)
Hepatocyte apoptotic process GO:0097284
Any apoptotic process in a hepatocyte, the main structural component of the liver.
1 P13020 (/ISO)
Positive regulation of keratinocyte apoptotic process GO:1902174
Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process.
1 P13020 (/ISO)
Terminal web assembly GO:1902896
The aggregation, arrangement and bonding together of a set of components to form a terminal web.
1 Q62468 (/IGI)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 Q62468 (/IGI)
Regulation of establishment of T cell polarity GO:1903903
Any process that modulates the frequency, rate or extent of establishment of T cell polarity.
1 P13020 (/ISO)
Regulation of plasma membrane raft polarization GO:1903906
Any process that modulates the frequency, rate or extent of plasma membrane raft polarization.
1 P13020 (/ISO)
Regulation of receptor clustering GO:1903909
Any process that modulates the frequency, rate or extent of receptor clustering.
1 P13020 (/ISO)
Positive regulation of protein processing in phagocytic vesicle GO:1903923
Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle.
1 P13020 (/IMP)
Amyloid fibril formation GO:1990000
The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
1 P13020 (/ISO)
Regulation of lamellipodium morphogenesis GO:2000392
Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis.
1 Q62468 (/IDA)
Positive regulation of lamellipodium morphogenesis GO:2000394
Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.
1 P09327 (/IGI)
Positive regulation of lamellipodium morphogenesis GO:2000394
Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.
1 P09327 (/IMP)
Positive regulation of lamellipodium morphogenesis GO:2000394
Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.
1 Q62468 (/ISO)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001269
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.
1 P13020 (/ISO)

There are 70 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 P13020 (/ISS) P20305 (/ISS) Q5R9H7 (/ISS) Q68FP1 (/ISS) Q6PAC1 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P13020 (/ISS) P20305 (/ISS) Q5R9H7 (/ISS) Q68FP1 (/ISS) Q6PAC1 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 B4DV78 (/IDA) P06396 (/IDA) P06396 (/IDA) P09327 (/IDA) Q9Y6U3 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
4 O75366 (/TAS) P06396 (/TAS) P06396 (/TAS) P10733 (/TAS)
Actin filament bundle GO:0032432
An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
4 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS) Q62468 (/ISS)
Filopodium tip GO:0032433
The end of a filopodium distal to the body of the cell.
4 P02640 (/ISS) P09327 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P06396 (/HDA) P06396 (/HDA) P09327 (/HDA) Q9Y6U3 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P06396 (/IDA) P06396 (/IDA) P20305 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P06396 (/IDA) P06396 (/IDA) Q68FP1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P06396 (/IDA) P06396 (/IDA) Q28046 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P06396 (/IDA) P06396 (/IDA) P20305 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P13020 (/ISO) Q60604 (/ISO) Q62468 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
3 P09327 (/IDA) P13020 (/IDA) Q62468 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
3 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
3 P02640 (/ISS) Q29261 (/ISS) Q3SZP7 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 E9PU64 (/IDA) Q68FP1 (/IDA) Q7TQ08 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
2 P09327 (/IDA) Q68FP1 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
2 P13020 (/ISO) Q62468 (/ISO)
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
2 P06396 (/IDA) P06396 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P06396 (/HDA) P06396 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P06396 (/NAS) P06396 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P06396 (/TAS) P06396 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P06396 (/TAS) P06396 (/TAS)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
2 P09327 (/IDA) Q62468 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
2 Q60604 (/IDA) Q62468 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P06396 (/HDA) P06396 (/HDA)
Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
2 P06396 (/IDA) P06396 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
2 P09327 (/IDA) Q62468 (/IDA)
Actin cap GO:0030478
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.
2 P06396 (/IDA) P06396 (/IDA)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
2 P06396 (/IDA) P06396 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P13020 (/ISO) Q60604 (/ISO)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
2 P06396 (/TAS) P06396 (/TAS)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
2 O75366 (/ISS) O88398 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 O75366 (/ISS) O88398 (/ISS)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
2 P06396 (/HDA) P06396 (/HDA)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
2 P06396 (/TAS) P06396 (/TAS)
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
1 P13020 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P13020 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P13020 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P13020 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P13020 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Y6U3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P13020 (/ISO)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 Q62468 (/ISO)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 P09327 (/ISS)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 Q62468 (/TAS)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q28046 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q9Y6U3 (/ISS)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q68FP1 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 P13020 (/ISO)
Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
1 P13020 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q62468 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 Q62468 (/ISO)
Actin cap GO:0030478
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.
1 P13020 (/ISO)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
1 P13020 (/ISO)
Actin filament bundle GO:0032432
An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
1 P09327 (/IDA)
Actin filament bundle GO:0032432
An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
1 Q62468 (/ISO)
Filopodium tip GO:0032433
The end of a filopodium distal to the body of the cell.
1 Q62468 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 Q9WU06 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 O88398 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9WU06 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 O88398 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 Q68FP1 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P13020 (/ISO)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P10733 (/HDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P13020 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q68FP1 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P13020 (/ISO)
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