The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Severin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 44: Cofilin/actin-depolymerizing factor homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
8 P45594 (/ISS) P45594 (/ISS) P45594 (/ISS) P45594 (/ISS) P45594 (/ISS) P45594 (/ISS) P45594 (/ISS) P45594 (/ISS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
3 Q580V7 (/IDA) Q580V7 (/IDA) Q580V7 (/IDA)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
8 P45594 (/TAS) P45594 (/TAS) P45594 (/TAS) P45594 (/TAS) P45594 (/TAS) P45594 (/TAS) P45594 (/TAS) P45594 (/TAS)
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Regulation of lamellipodium assembly GO:0010591
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Epithelial structure maintenance GO:0010669
A tissue homeostatic process required for the maintenance of epithelial structure.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Lamellipodium assembly GO:0030032
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Meiotic cytokinesis GO:0033206
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Imaginal disc-derived leg segmentation GO:0036011
Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Rhabdomere development GO:0042052
The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Establishment of ommatidial planar polarity GO:0042067
The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
8 P45594 (/IGI) P45594 (/IGI) P45594 (/IGI) P45594 (/IGI) P45594 (/IGI) P45594 (/IGI) P45594 (/IGI) P45594 (/IGI)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Centrosome separation GO:0051299
The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
8 P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP) P45594 (/IMP)
Centriole replication GO:0007099
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
4 E9ADQ2 (/ISO) Q580V7 (/ISO) Q580V7 (/ISO) Q580V7 (/ISO)
Intracellular transport GO:0046907
The directed movement of substances within a cell.
4 E9ADQ2 (/ISO) Q580V7 (/ISO) Q580V7 (/ISO) Q580V7 (/ISO)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
4 E9ADQ2 (/ISO) Q580V7 (/ISO) Q580V7 (/ISO) Q580V7 (/ISO)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
1 E9ADQ2 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA) P45594 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q580V7 (/IDA) Q580V7 (/IDA) Q580V7 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
3 Q580V7 (/IDA) Q580V7 (/IDA) Q580V7 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
3 Q580V7 (/IDA) Q580V7 (/IDA) Q580V7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 E9ADQ2 (/ISO)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
1 E9ADQ2 (/ISO)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 E9ADQ2 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...