The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Severin
".
FunFam 39: Villin-4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
			The search results have been sorted with the annotations that are found most frequently at the top of the
			list. The results can be filtered by typing text into the search box at the top of the table.
			
			
	| GO Term | Annotations | Evidence | 
|---|---|---|
| Actin filament binding GO:0051015 Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. | 4 | B8ATT7 (/ISS) Q0J716 (/ISS) Q0JAD9 (/ISS) Q67U26 (/ISS) | 
| Actin filament binding GO:0051015 Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. | 3 | O81645 (/IDA) Q10L71 (/IDA) Q67U26 (/IDA) | 
| Protein binding GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | 2 | O81644 (/IPI) O81644 (/IPI) | 
| Actin monomer binding GO:0003785 Interacting selectively and non-covalently with monomeric actin, also known as G-actin. | 1 | P36418 (/IDA) | 
There are 18 GO terms relating to "biological process"
			The search results have been sorted with the annotations that are found most frequently at the top of the
			list. The results can be filtered by typing text into the search box at the top of the table.
			
			
	| GO Term | Annotations | Evidence | 
|---|---|---|
| Actin filament severing GO:0051014 The process in which an actin filament is broken down into smaller filaments. | 5 | O65570 (/IDA) O65570 (/IDA) O81645 (/IDA) Q10L71 (/IDA) Q67U26 (/IDA) | 
| Actin filament organization GO:0007015 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. | 4 | B8ATT7 (/ISS) Q0J716 (/ISS) Q0JAD9 (/ISS) Q67U26 (/ISS) | 
| Actin filament severing GO:0051014 The process in which an actin filament is broken down into smaller filaments. | 4 | B8ATT7 (/ISS) Q0J716 (/ISS) Q0JAD9 (/ISS) Q67U26 (/ISS) | 
| Actin filament capping GO:0051693 The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. | 4 | B8ATT7 (/ISS) Q0J716 (/ISS) Q0JAD9 (/ISS) Q67U26 (/ISS) | 
| Actin filament bundle assembly GO:0051017 The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. | 3 | O81644 (/IGI) O81644 (/IGI) O81645 (/IGI) | 
| Actin filament organization GO:0007015 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. | 2 | Q10L71 (/IDA) Q67U26 (/IDA) | 
| Actin filament organization GO:0007015 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. | 2 | O65570 (/IMP) O65570 (/IMP) | 
| Response to abscisic acid GO:0009737 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. | 2 | O65570 (/IDA) O65570 (/IDA) | 
| Actin filament depolymerization GO:0030042 Disassembly of actin filaments by the removal of actin monomers from a filament. | 2 | O65570 (/IDA) O65570 (/IDA) | 
| Root hair elongation GO:0048767 The process in which the root hair grows longer. | 2 | O65570 (/IMP) O65570 (/IMP) | 
| Actin filament capping GO:0051693 The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. | 2 | Q10L71 (/IDA) Q67U26 (/IDA) | 
| Cytoplasmic streaming GO:0099636 The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains. | 2 | O65570 (/IMP) O65570 (/IMP) | 
| Regulation of cell growth GO:0001558 Any process that modulates the frequency, rate, extent or direction of cell growth. | 1 | Q10L71 (/IMP) | 
| Gravitropism GO:0009630 The orientation of plant parts under the stimulation of gravity. | 1 | Q10L71 (/IMP) | 
| Barbed-end actin filament capping GO:0051016 The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. | 1 | P36418 (/IDA) | 
| Actin filament bundle assembly GO:0051017 The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. | 1 | O81645 (/IDA) | 
| Response to calcium ion GO:0051592 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. | 1 | Q67U26 (/IDA) | 
| Regulation of auxin polar transport GO:2000012 Any process that modulates the frequency, rate or extent of auxin polar transport. | 1 | Q10L71 (/IMP) | 
There are 5 GO terms relating to "cellular component"
			The search results have been sorted with the annotations that are found most frequently at the top of the
			list. The results can be filtered by typing text into the search box at the top of the table.
			
			
	| GO Term | Annotations | Evidence | 
|---|---|---|
| Actin filament bundle GO:0032432 An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. | 4 | B8ATT7 (/ISS) Q0J716 (/ISS) Q0JAD9 (/ISS) Q67U26 (/ISS) | 
| Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | 2 | O65570 (/IDA) O65570 (/IDA) | 
| Actin filament bundle GO:0032432 An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. | 2 | Q10L71 (/IDA) Q67U26 (/IDA) | 
| Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | 1 | O81645 (/IDA) | 
| Actin filament GO:0005884 A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. | 1 | O81645 (/IDA) | 
