The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Severin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Twinfilin-1 isoform 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q12792 (/IPI) Q6IBS0 (/IPI) Q6IBS0 (/IPI) Q6IBS0 (/IPI) Q6IBS0 (/IPI) Q91YR1 (/IPI)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
5 Q12792 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
5 Q12792 (/IDA) Q6IBS0 (/IDA) Q6IBS0 (/IDA) Q6IBS0 (/IDA) Q6IBS0 (/IDA)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
5 Q12792 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
5 Q12792 (/HDA) Q6IBS0 (/HDA) Q6IBS0 (/HDA) Q6IBS0 (/HDA) Q6IBS0 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 Q6IBS0 (/HDA) Q6IBS0 (/HDA) Q6IBS0 (/HDA) Q6IBS0 (/HDA)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
4 Q6IBS0 (/IPI) Q6IBS0 (/IPI) Q6IBS0 (/IPI) Q6IBS0 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
3 Q56JV6 (/ISS) Q5R7N2 (/ISS) Q5RJR2 (/ISS)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
2 Q91YR1 (/IDA) Q9Z0P5 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q91YR1 (/ISO) Q9Z0P5 (/ISO)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
2 Q91YR1 (/IDA) Q9Z0P5 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q12792 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q91YR1 (/ISO)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q91YR1 (/IDA)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 Q9Z0P5 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q91YR1 (/IPI)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
5 Q12792 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
5 Q6IBS0 (/IC) Q6IBS0 (/IC) Q6IBS0 (/IC) Q6IBS0 (/IC) Q9Z0P5 (/IC)
Sequestering of actin monomers GO:0042989
The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.
5 Q12792 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Positive regulation of lamellipodium assembly GO:0010592
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
4 Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
4 Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
4 Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
4 Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP)
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
4 Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
4 Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
4 Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP) Q6IBS0 (/IMP)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
2 Q91YR1 (/IDA) Q9Z0P5 (/IDA)
Positive regulation of lamellipodium assembly GO:0010592
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
1 Q9Z0P5 (/ISO)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
1 Q91YR1 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q9Z0P5 (/ISO)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q9Z0P5 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q9Z0P5 (/ISO)
Sequestering of actin monomers GO:0042989
The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.
1 Q91YR1 (/IDA)
Regulation of actin phosphorylation GO:0043538
Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.
1 Q12792 (/IDA)
Regulation of actin phosphorylation GO:0043538
Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.
1 Q91YR1 (/ISO)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 Q9Z0P5 (/ISO)
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
1 Q91YR1 (/IDA)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 Q9Z0P5 (/ISO)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 Q9Z0P5 (/ISO)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
5 Q12792 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
5 Q12792 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
5 Q12792 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q6IBS0 (/IDA) Q6IBS0 (/IDA) Q6IBS0 (/IDA) Q6IBS0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q6IBS0 (/NAS) Q6IBS0 (/NAS) Q6IBS0 (/NAS) Q6IBS0 (/NAS)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
4 Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
4 Q6IBS0 (/IDA) Q6IBS0 (/IDA) Q6IBS0 (/IDA) Q6IBS0 (/IDA)
Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
4 Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS) Q6IBS0 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q6IBS0 (/HDA) Q6IBS0 (/HDA) Q6IBS0 (/HDA) Q6IBS0 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 F8VS81 (/IDA) F8VS81 (/IDA) Q12792 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
2 Q12792 (/ISS) Q5ZLN3 (/ISS)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
2 Q91YR1 (/IDA) Q9Z0P5 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q91YR1 (/IDA) Q9Z0P5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Z0P5 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q91YR1 (/ISO)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q91YR1 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q12792 (/ISS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q12792 (/HDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q91YR1 (/IDA)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
1 Q91YR1 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q9Z0P5 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q9Z0P5 (/ISO)
Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
1 Q9Z0P5 (/IDA)
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