The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Transcriptional regulator, LysR family

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
96 P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS)
(86 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
68 P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA)
(58 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P76250 (/IMP) P76250 (/IMP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 B3G2A3 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 B3G2A3 (/IMP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
1 B3G2A3 (/IDA)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
1 B3G2A3 (/IMP)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
68 P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA) P45463 (/IDA)
(58 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
68 P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS) P45463 (/ISS)
(58 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
28 Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS) Q9KKW8 (/ISS)
(18 more)
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
10 Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP) Q9I150 (/EXP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
9 P37641 (/ISS) P37641 (/ISS) P37641 (/ISS) P37641 (/ISS) P37641 (/ISS) P37641 (/ISS) P37641 (/ISS) P37641 (/ISS) P37641 (/ISS)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
7 Q9HZX0 (/IMP) Q9HZX0 (/IMP) Q9HZX0 (/IMP) Q9HZX0 (/IMP) Q9HZX0 (/IMP) Q9HZX0 (/IMP) Q9HZX0 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
4 Q4KCZ2 (/IGC) Q4KCZ2 (/IGC) Q4KCZ2 (/IGC) Q4KCZ2 (/IGC)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
2 P76250 (/IMP) P76250 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P76250 (/IMP) P76250 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P76250 (/IMP) P76250 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 B3G2A3 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 B3G2A3 (/IMP)
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