The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Periplasmic binding protein-like II
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Porphobilinogen deaminase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
25 O94048 (/IMP) O94048 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP)
(15 more)
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
18 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(8 more)
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
2 P08397 (/TAS) P08397 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P19356 (/IPI) Q43316 (/IPI)
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
1 P22907 (/ISO)
Hydroxymethylbilane synthase activity GO:0004418
Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
1 Q54P93 (/ISS)
Uroporphyrinogen-III synthase activity GO:0004852
Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III.
1 P19356 (/IDA)
Uroporphyrinogen-III synthase activity GO:0004852
Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III.
1 P22907 (/ISO)
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
1 P19356 (/IPI)
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
1 P22907 (/ISO)
Amine binding GO:0043176
Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
1 P19356 (/IPI)
Amine binding GO:0043176
Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
1 P22907 (/ISO)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 P19356 (/IPI)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 P22907 (/ISO)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
23 O94048 (/IMP) O94048 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP)
(13 more)
Tetrapyrrole biosynthetic process GO:0033014
The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
15 P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP) P06983 (/IMP)
(5 more)
Protoporphyrinogen IX biosynthetic process GO:0006782
The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Peptidyl-pyrromethane cofactor linkage GO:0018160
The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine.
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
2 P08397 (/IC) P08397 (/IC)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
2 P08397 (/TAS) P08397 (/TAS)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 O94048 (/IMP) O94048 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P19356 (/IEP)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
1 Q54P93 (/ISS)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P19356 (/IEP)
Response to carbohydrate GO:0009743
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
1 P19356 (/IEP)
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
1 P19356 (/IEP)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 P19356 (/IEP)
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 P19356 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P19356 (/IEP)
Chlorophyll biosynthetic process GO:0015995
The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.
1 Q43316 (/TAS)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P19356 (/IEP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P19356 (/IEP)
Response to cobalt ion GO:0032025
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
1 P19356 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P19356 (/IEP)
Tetrapyrrole biosynthetic process GO:0033014
The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
1 P19356 (/IDA)
Tetrapyrrole biosynthetic process GO:0033014
The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
1 P22907 (/ISO)
Response to vitamin GO:0033273
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.
1 P19356 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P19356 (/IEP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q43316 (/IEP)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 P19356 (/IEP)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
1 P19356 (/IEP)
Response to methylmercury GO:0051597
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.
1 P19356 (/IEP)
Cellular response to antibiotic GO:0071236
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P19356 (/IEP)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 P19356 (/IEP)
Cellular response to lead ion GO:0071284
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 P19356 (/IEP)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P19356 (/IEP)
Cellular response to amine stimulus GO:0071418
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
1 P19356 (/IEP)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 P19356 (/IEP)
Chloroplast RNA modification GO:1900865
Any RNA modification that takes place in chloroplast.
1 Q43316 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
15 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA) P06983 (/IDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA) P28789 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P08397 (/TAS) P08397 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P19356 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P22907 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P22907 (/ISO)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q43316 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q43316 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 Q43316 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P19356 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P22907 (/ISO)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 Q43316 (/IDA)
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