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CATH Superfamily 3.40.140.10

Cytidine Deaminase, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytidine Deaminase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47: Apolipoprotein B editing enzyme catalytic polypept...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Single-stranded DNA cytosine deaminase. [EC: 3.5.4.38]
Cytosine in single-stranded DNA + H(2)O = uracil in single-stranded DNA + NH(3).
  • The enzyme exclusively catalyzes deamination of cytosine in single- stranded DNA.
  • It preferentially deaminates five-nucleotide bubbles.
  • The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G).
  • The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
 7 A0A0K0MJ49 A0A0K0MJ49 P31941 P31941 Q19Q52 Q1WBT4 Q6NTF7
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