The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pyruvate kinase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Pyruvate kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 P11974 (/IPI) P11980 (/IPI) P14618 (/IPI) P14618 (/IPI) P14618 (/IPI) P14618 (/IPI) P14618 (/IPI) P52480 (/IPI) P52480 (/IPI) P52480 (/IPI)
(5 more)
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
9 P11980 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P52480 (/IDA) P52480 (/IDA) P52480 (/IDA)
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
6 P00548 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA)
MHC class II protein complex binding GO:0023026
Interacting selectively and non-covalently with the class II major histocompatibility complex.
5 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
5 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA)
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Thyroid hormone binding GO:0070324
Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P11980 (/IDA)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
1 P11980 (/IDA)
Thyroid hormone binding GO:0070324
Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
1 P11980 (/IDA)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
7 P11974 (/ISS) P11979 (/ISS) P11980 (/ISS) P52480 (/ISS) P52480 (/ISS) P52480 (/ISS) Q5NVN0 (/ISS)
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
5 P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
5 P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
5 P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
5 P14618 (/IMP) P14618 (/IMP) P14618 (/IMP) P14618 (/IMP) P14618 (/IMP)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
4 P11980 (/IDA) P52480 (/IDA) P52480 (/IDA) P52480 (/IDA)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
ATP biosynthetic process GO:0006754
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Pyruvate biosynthetic process GO:0042866
The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P11980 (/IEP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 P11980 (/IDA)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 A7MCK8 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 P11980 (/IDA)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
1 P00548 (/TAS)
ATP biosynthetic process GO:0006754
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P11980 (/IDA)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P11980 (/IEP)
Response to gravity GO:0009629
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
1 P11980 (/IEP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P11980 (/IEP)
Response to muscle inactivity GO:0014870
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus.
1 P11980 (/IEP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P11980 (/IDA)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P11980 (/IEP)
Pyruvate biosynthetic process GO:0042866
The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.
1 P11980 (/IDA)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
1 P11980 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P11980 (/IDA)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
16 A0A024R5Z9 (/IDA) A0A024R5Z9 (/IDA) A0A024R5Z9 (/IDA) A0A024R5Z9 (/IDA) H3BTN5 (/IDA) H3BTN5 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA)
(6 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P52480 (/HDA) P52480 (/HDA) P52480 (/HDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
8 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P52480 (/HDA) P52480 (/HDA) P52480 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P00548 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P14618 (/NAS) P14618 (/NAS) P14618 (/NAS) P14618 (/NAS) P14618 (/NAS)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
5 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
5 P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA)
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
5 P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
5 P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
3 P52480 (/IDA) P52480 (/IDA) P52480 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
3 P52480 (/HDA) P52480 (/HDA) P52480 (/HDA)
Pyruvate kinase complex GO:1902912
A protein complex which is capable of pyruvate kinase activity.
3 P52480 (/ISO) P52480 (/ISO) P52480 (/ISO)
Pyruvate kinase complex GO:1902912
A protein complex which is capable of pyruvate kinase activity.
1 P11980 (/IDA)