The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pyruvate kinase, C-terminal domain
".
FunFam 1: Pyruvate kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
|
26 |
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
(16 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
15 |
P11974 (/IPI)
P11980 (/IPI)
P14618 (/IPI)
P14618 (/IPI)
P14618 (/IPI)
P14618 (/IPI)
P14618 (/IPI)
P52480 (/IPI)
P52480 (/IPI)
P52480 (/IPI)
(5 more) |
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
|
12 |
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
(2 more) |
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
|
7 | P00548 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P30613 (/TAS) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
5 | P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) |
MHC class II protein complex binding GO:0023026
Interacting selectively and non-covalently with the class II major histocompatibility complex.
|
5 | P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
5 | P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) |
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
|
4 | P52480 (/ISO) P52480 (/ISO) P52480 (/ISO) P53657 (/ISO) |
Pyruvate kinase activity GO:0004743
Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
|
4 | O62619 (/ISS) P46614 (/ISS) Q8T434 (/ISS) Q9VQH0 (/ISS) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | P52480 (/ISO) P52480 (/ISO) P52480 (/ISO) |
Showing 1 to 10 of 16 entries
There are 65 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
|
12 |
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
P00549 (/IMP)
(2 more) |
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
|
10 | P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) P00549 (/IMP) |
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
|
7 | P11974 (/ISS) P11979 (/ISS) P11980 (/ISS) P52480 (/ISS) P52480 (/ISS) P52480 (/ISS) Q5NVN0 (/ISS) |
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
|
6 | P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P30613 (/TAS) |
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
|
5 | P11980 (/IDA) P12928 (/IDA) P52480 (/IDA) P52480 (/IDA) P52480 (/IDA) |
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
|
5 | P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
5 | P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) |
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
|
5 | P14618 (/IMP) P14618 (/IMP) P14618 (/IMP) P14618 (/IMP) P14618 (/IMP) |
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
|
4 | P52480 (/ISO) P52480 (/ISO) P52480 (/ISO) P53657 (/ISO) |
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
|
4 | O62619 (/ISS) P46614 (/ISS) Q8T434 (/ISS) Q9VQH0 (/ISS) |
Showing 1 to 10 of 65 entries
There are 35 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
18 |
A0A024R5Z9 (/IDA)
A0A024R5Z9 (/IDA)
A0A024R5Z9 (/IDA)
A0A024R5Z9 (/IDA)
O62619 (/IDA)
P12928 (/IDA)
P14618 (/IDA)
P14618 (/IDA)
P14618 (/IDA)
P14618 (/IDA)
(8 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
16 |
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
P00549 (/IDA)
(6 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
10 | P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) P00549 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
8 | P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P52480 (/HDA) P52480 (/HDA) P52480 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | P00548 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P30613 (/TAS) P53657 (/TAS) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
8 | P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P52480 (/HDA) P52480 (/HDA) P52480 (/HDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
6 | P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P30613 (/HDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
5 | P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) P14618 (/TAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) P14618 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) P14618 (/IDA) |
Showing 1 to 10 of 35 entries