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CATH Superfamily 3.40.1370.10

Ribosomal protein L4/L1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein L4/L1

This superfamily entry consists of the ribosomal protein L4 found in the large subunit of the ribosome in eukaryotes and archaebacteria.

L4 is among the largest ribosomal proteins, playing a crucial role in the early assembly of the large subunit. It consists of a single domain and exhibits an alpha/beta fol with an open beta-sheet topology. L4 has a well defined and conserved hydrophobic core which stabilises the overall structure. L4 in yeast has been shown to bind to 25S rRNA. L4 was the first protein shown to inhibit not only the translation but also the transcription of its S10 operon. Escherichia coli L4 seems to exhibit separate rRNA- (N-terminal) and mRNA- (C-terminal) binding modules.

PFAM:PF00573, INTERPRO:IPR023574,PMID:9838082,PMID:10698923

GO Diversity

Unique GO annotations
64 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
17963 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 132
Domain clusters (>95% seq id): 12
Domain clusters (>35% seq id): 7
Unique PDBs: 132
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 51
Function
Unique EC:
Unique GO: 64
Taxonomy
Unique Species: 17963