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CATH Superfamily 3.40.1190.10

Mur-like, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Mur-like, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Dihydrofolate synthase/folylpolyglutamate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tetrahydrofolylpolyglutamate synthase activity GO:0004326
Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
 23 P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA)
(13 more)
Dihydrofolate synthase activity GO:0008841
Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.
 23 P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA)
(13 more)
Tetrahydrofolylpolyglutamate synthase activity GO:0004326
Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).
 19 A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS)
(9 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
 10 O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
 10 O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
 10 O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA) O53174 (/IDA)
Dihydrofolate synthase activity GO:0008841
Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.
 7 Q8ECR5 (/ISS) Q9KTA2 (/ISS) Q9KTA2 (/ISS) Q9KTA2 (/ISS) Q9KTA2 (/ISS) Q9KTA2 (/ISS) Q9KTA2 (/ISS)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Folic acid-containing compound metabolic process GO:0006760
The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
 19 A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS) A0A0F7RBH1 (/ISS)
(9 more)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 23 P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA) P08192 (/IDA)
(13 more)