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CATH Superfamily 3.40.1180.10

Decaprenyl diphosphate synthase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Decaprenyl diphosphate synthase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: (2E,6E)-farnesyl-diphosphate-specific ditrans,poly...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific). [EC: 2.5.1.31]
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.
  • Undecaprenyl pyrophosphate synthase catalyzes the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall.
 9149 A0A023YS86 A0A023YS86 A0A023YS86 A0A023YS86 A0A023YS86 A0A023YS86 A0A023YS86 A0A023YS86 A0A023YS86 A0A023YS86
(9139 more...)
(2Z,6Z)-farnesyl diphosphate synthase. [EC: 2.5.1.92]
Dimethylallyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate.
  • This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate.
  • In wild tomato it is involved in the biosynthesis of several sesquiterpenes.
  • Cf. EC 2.5.1.68 and EC 2.5.1.10.
 4 B8XA40 B8XA40 R9R6F8 R9R6F8
Dimethylallylcistransferase. [EC: 2.5.1.28]
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate.
  • Will not use larger prenyl diphosphates as efficient donors.
 4 C1K5M2 C1K5M2 R9R6P8 R9R6P8
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific). [EC: 2.5.1.87]
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55).
  • The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation.
  • The yeast Saccharomyces cerevisiae has two different enzymes that catalyze this reaction.
  • Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits.
  • Largest Srt1p products reach C(290).
  • The enzyme from Arabidopsis thaliana catalyzes the formation of polyprenyl diphosphates with predominant carbon number C(120).
 1 O80458
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