The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calcium-transporting ATPase, cytoplasmic domain N
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Calcium-transporting ATPase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P23634 (/IPI) Q6Q477 (/IPI)
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
1 P23634 (/IMP)
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
1 Q6Q477 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 P23634 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q6Q477 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q6Q477 (/ISO)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q6Q477 (/ISO)
Protein phosphatase 2B binding GO:0030346
Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.
1 P23634 (/IDA)
Protein phosphatase 2B binding GO:0030346
Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.
1 Q6Q477 (/ISO)
Nitric-oxide synthase inhibitor activity GO:0036487
Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase.
1 P23634 (/IDA)
Nitric-oxide synthase inhibitor activity GO:0036487
Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase.
1 Q6Q477 (/ISO)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 P23634 (/IPI)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 Q6Q477 (/ISO)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 F7AAP4 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 P23634 (/ISS)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 D3K0R6 (/ISS) P23634 (/ISS)
Urinary bladder smooth muscle contraction GO:0014832
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
2 D3K0R6 (/ISS) P23634 (/ISS)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
2 D3K0R6 (/ISS) P23634 (/ISS)
Negative regulation of peptidyl-cysteine S-nitrosylation GO:1902083
Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.
2 F7AAP4 (/NAS) P23634 (/NAS)
Regulation of sodium ion transmembrane transport GO:1902305
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport.
2 F7AAP4 (/IC) P23634 (/IC)
Negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.
2 P23634 (/IMP) Q6Q477 (/IMP)
Cellular response to acetylcholine GO:1905145
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.
2 D3K0R6 (/ISS) P23634 (/ISS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P23634 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q6Q477 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6Q477 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6Q477 (/TAS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 P23634 (/IC)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 P23634 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q6Q477 (/IMP)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q6Q477 (/ISO)
Negative regulation of nitric oxide mediated signal transduction GO:0010751
Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
1 P23634 (/IDA)
Negative regulation of nitric oxide mediated signal transduction GO:0010751
Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
1 Q6Q477 (/ISO)
Urinary bladder smooth muscle contraction GO:0014832
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
1 Q6Q477 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q6Q477 (/IMP)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 P23634 (/IDA)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 Q6Q477 (/ISO)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 P23634 (/TAS)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 P23634 (/IDA)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q6Q477 (/ISO)
Negative regulation of nitric-oxide synthase activity GO:0051001
Any process that stops or reduces the activity of the enzyme nitric-oxide synthase.
1 P23634 (/IDA)
Negative regulation of nitric-oxide synthase activity GO:0051001
Any process that stops or reduces the activity of the enzyme nitric-oxide synthase.
1 Q6Q477 (/ISO)
Response to hydrostatic pressure GO:0051599
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.
1 P23634 (/IMP)
Response to hydrostatic pressure GO:0051599
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.
1 Q6Q477 (/ISO)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 P23634 (/IMP)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q6Q477 (/ISO)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
1 P23634 (/IDA)
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
1 Q6Q477 (/ISO)
Cellular response to epinephrine stimulus GO:0071872
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
1 P23634 (/IDA)
Cellular response to epinephrine stimulus GO:0071872
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
1 Q6Q477 (/ISO)
Calcium ion transmembrane import into cytosol GO:0097553
A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore.
1 P23634 (/IC)
Calcium ion import across plasma membrane GO:0098703
The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.
1 P23634 (/IC)
Negative regulation of the force of heart contraction GO:0098736
Any process that decreases the force of heart muscle contraction.
1 P23634 (/IDA)
Negative regulation of the force of heart contraction GO:0098736
Any process that decreases the force of heart muscle contraction.
1 Q6Q477 (/ISO)
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process GO:0140199
Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
1 P23634 (/IDA)
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process GO:0140199
Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
1 Q6Q477 (/ISO)
Negative regulation of arginine catabolic process GO:1900082
Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process.
1 P23634 (/IDA)
Negative regulation of arginine catabolic process GO:1900082
Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process.
1 Q6Q477 (/ISO)
Calcium ion export GO:1901660
The directed movement of calcium ion out of a cell or organelle.
1 Q6Q477 (/ISO)
Regulation of cell cycle G1/S phase transition GO:1902806
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
1 P23634 (/IMP)
Regulation of cell cycle G1/S phase transition GO:1902806
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
1 Q6Q477 (/ISO)
Negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.
1 Q6Q477 (/ISO)
Negative regulation of citrulline biosynthetic process GO:1903249
Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process.
1 P23634 (/IDA)
Negative regulation of citrulline biosynthetic process GO:1903249
Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process.
1 Q6Q477 (/ISO)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
1 P23634 (/TAS)
Cellular response to acetylcholine GO:1905145
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.
1 Q6Q477 (/IMP)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 P23634 (/IDA)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 Q6Q477 (/ISO)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 A0A024R968 (/IDA) A0A024R968 (/IDA) P23634 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P23634 (/TAS) Q6Q477 (/TAS)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
2 P23634 (/IDA) Q6Q477 (/IDA)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
2 D3K0R6 (/ISS) P23634 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q6Q477 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P23634 (/TAS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 P23634 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P23634 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P23634 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q6Q477 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q6Q477 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 P23634 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q6Q477 (/ISO)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 Q6Q477 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 F7AAP4 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P23634 (/ISS)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
1 Q6Q477 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 Q6Q477 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q6Q477 (/ISO)
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
1 Q6Q477 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q6Q477 (/ISO)
Integral component of presynaptic active zone membrane GO:0099059
The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6Q477 (/ISO)
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