The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Threonyl-trna Synthetase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Threonine--tRNA ligase, cytoplasmic

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Threonine-tRNA ligase activity GO:0004829
Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
7 A2RTX5 (/ISS) A6QNM8 (/ISS) P26639 (/ISS) P26639 (/ISS) Q0V9S0 (/ISS) Q3ZBV8 (/ISS) Q5XHY5 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 A2RTX5 (/IPI) B2RDX5 (/IPI) P26639 (/IPI) P26639 (/IPI) Q53GX7 (/IPI)
Threonine-tRNA ligase activity GO:0004829
Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
4 Q8IGC5 (/TAS) Q8IP94 (/TAS) Q8MRL7 (/TAS) Q9VKB0 (/TAS)
Threonine-tRNA ligase activity GO:0004829
Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
2 Q8BLY2 (/IDA) Q9D0R2 (/IDA)
Threonine-tRNA ligase activity GO:0004829
Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
2 P26639 (/NAS) P26639 (/NAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P26639 (/NAS) P26639 (/NAS)
Threonine-tRNA ligase activity GO:0004829
Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
1 Q9D0R2 (/IMP)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
8 A0A2R8PXY1 (/IMP) A0A2R8QAT8 (/IMP) A0A2R8QDW5 (/IMP) A0A2R8QF48 (/IMP) A0A2R8QSD2 (/IMP) A0A2R8RVT1 (/IMP) A2BIM7 (/IMP) A8KC60 (/IMP)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
8 A0A2R8PXY1 (/IMP) A0A2R8QAT8 (/IMP) A0A2R8QDW5 (/IMP) A0A2R8QF48 (/IMP) A0A2R8QSD2 (/IMP) A0A2R8RVT1 (/IMP) A2BIM7 (/IMP) A8KC60 (/IMP)
Regulation of sprouting angiogenesis GO:1903670
Any process that modulates the frequency, rate or extent of sprouting angiogenesis.
8 A0A2R8PXY1 (/IMP) A0A2R8QAT8 (/IMP) A0A2R8QDW5 (/IMP) A0A2R8QF48 (/IMP) A0A2R8QSD2 (/IMP) A0A2R8RVT1 (/IMP) A2BIM7 (/IMP) A8KC60 (/IMP)
Threonyl-tRNA aminoacylation GO:0006435
The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.
7 A2RTX5 (/ISS) A6QNM8 (/ISS) P26639 (/ISS) P26639 (/ISS) Q0V9S0 (/ISS) Q3ZBV8 (/ISS) Q5XHY5 (/ISS)
Threonyl-tRNA aminoacylation GO:0006435
The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.
4 Q8IGC5 (/TAS) Q8IP94 (/TAS) Q8MRL7 (/TAS) Q9VKB0 (/TAS)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
2 P26639 (/NAS) P26639 (/NAS)
TRNA aminoacylation for protein translation GO:0006418
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
2 P26639 (/TAS) P26639 (/TAS)
Threonyl-tRNA aminoacylation GO:0006435
The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.
2 Q8BLY2 (/IDA) Q9D0R2 (/IDA)
Threonyl-tRNA aminoacylation GO:0006435
The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.
2 P26639 (/NAS) P26639 (/NAS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
2 P52709 (/IGI) Q86D21 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
2 P52709 (/IMP) Q86D21 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A2RTX5 (/ISS) A6QNM8 (/ISS) Q0V9S0 (/ISS) Q3ZBV8 (/ISS) Q5XHY5 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q8IGC5 (/TAS) Q8IP94 (/TAS) Q8MRL7 (/TAS) Q9VKB0 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q8IGC5 (/TAS) Q8IP94 (/TAS) Q8MRL7 (/TAS) Q9VKB0 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A2RTX5 (/ISS) A6QNM8 (/ISS) Q0V9S0 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8BLY2 (/IDA) Q9D0R2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P26639 (/NAS) P26639 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P26639 (/IDA) P26639 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P26639 (/TAS) P26639 (/TAS)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
2 P26639 (/IDA) P26639 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P26639 (/HDA) P26639 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BLY2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9D0R2 (/ISO)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q9D0R2 (/ISO)