The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
eRF1 domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Eukaryotic peptide chain release factor subunit 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
12 O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P79063 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P79063 (/IPI)
Translation release factor activity, codon specific GO:0016149
A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site.
1 P79063 (/TAS)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
1 P79063 (/EXP)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of translational termination GO:0006449
Any process that modulates the frequency, rate or extent of translational termination.
12 O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS)
(2 more)
Cytoplasmic translational termination GO:0002184
The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
1 P79063 (/IPI)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P79063 (/HDA)
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
1 P79063 (/IDA)
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
1 P79063 (/IMP)
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
1 P79063 (/IPI)
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