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CATH Superfamily 3.30.930.10

Bira Bifunctional Protein; Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Bira Bifunctional Protein; Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 139: O-phosphoserine--tRNA(Cys) ligase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
O-phosphoserine--tRNA ligase. [EC: 6.1.1.27]
ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L- seryl-tRNA(Cys).
  • In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys).
  • The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism.
  • Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73.
  • Formerly EC 6.1.1.n2.
 16 A0A075WH96 A0A075WH96 A0A075WH96 A0A0E3QR46 A0A0E3QR46 A0A117KUH8 A0A117KUH8 A0A117KUH8 O30126 O30126
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