The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Frataxin/CyaY
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Frataxin, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Iron chaperone activity GO:0034986
Directly binding to and delivering iron ions to a target protein.
3 Q16595 (/IDA) Q16595 (/IDA) Q9W385 (/IDA)
Ferroxidase activity GO:0004322
Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
2 Q16595 (/IDA) Q16595 (/IDA)
Ferroxidase activity GO:0004322
Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
2 O35943 (/ISO) O35943 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q16595 (/IPI) Q16595 (/IPI)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
2 Q16595 (/IDA) Q16595 (/IDA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
2 O35943 (/ISO) O35943 (/ISO)
Ferric iron binding GO:0008199
Interacting selectively and non-covalently with ferric iron, Fe(III).
2 Q16595 (/IDA) Q16595 (/IDA)
Ferric iron binding GO:0008199
Interacting selectively and non-covalently with ferric iron, Fe(III).
2 O35943 (/ISO) O35943 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 O35943 (/ISO) O35943 (/ISO)
Iron chaperone activity GO:0034986
Directly binding to and delivering iron ions to a target protein.
2 O35943 (/ISO) O35943 (/ISO)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
2 Q16595 (/IDA) Q16595 (/IDA)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
2 O35943 (/ISO) O35943 (/ISO)
Metallochaperone activity GO:0016530
Directly binding to and delivering metal ions to a target protein.
1 D3ZYW7 (/NAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 D3ZYW7 (/IPI)

There are 58 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
4 O35943 (/IMP) O35943 (/IMP) Q16595 (/IMP) Q16595 (/IMP)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
3 Q16595 (/IMP) Q16595 (/IMP) Q9W385 (/IMP)
Oxidative phosphorylation GO:0006119
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
2 O35943 (/IMP) O35943 (/IMP)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
2 Q16595 (/NAS) Q16595 (/NAS)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 O35943 (/ISO) O35943 (/ISO)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 O35943 (/IMP) O35943 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
2 O35943 (/IMP) O35943 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 Q16595 (/IMP) Q16595 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 O35943 (/ISO) O35943 (/ISO)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
2 O35943 (/IMP) O35943 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
2 O35943 (/IMP) O35943 (/IMP)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
2 O35943 (/ISO) O35943 (/ISO)
Regulation of ferrochelatase activity GO:0010722
Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+.
2 Q16595 (/IDA) Q16595 (/IDA)
Regulation of ferrochelatase activity GO:0010722
Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+.
2 O35943 (/ISO) O35943 (/ISO)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
2 Q16595 (/IDA) Q16595 (/IDA)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
2 O35943 (/IMP) O35943 (/IMP)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
2 O35943 (/ISO) O35943 (/ISO)
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
2 Q16595 (/IDA) Q16595 (/IDA)
Protein autoprocessing GO:0016540
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
2 O35943 (/ISO) O35943 (/ISO)
Iron incorporation into metallo-sulfur cluster GO:0018283
The incorporation of iron into a metallo-sulfur cluster.
2 Q16595 (/IDA) Q16595 (/IDA)
Iron incorporation into metallo-sulfur cluster GO:0018283
The incorporation of iron into a metallo-sulfur cluster.
2 O35943 (/ISO) O35943 (/ISO)
Proprioception GO:0019230
The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors.
2 O35943 (/IMP) O35943 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 Q16595 (/IMP) Q16595 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 O35943 (/ISO) O35943 (/ISO)
Negative regulation of multicellular organism growth GO:0040015
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
2 O35943 (/IMP) O35943 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q16595 (/IMP) Q16595 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 O35943 (/ISO) O35943 (/ISO)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
2 Q16595 (/IMP) Q16595 (/IMP)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
2 O35943 (/ISO) O35943 (/ISO)
Small molecule metabolic process GO:0044281
The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
2 Q16595 (/TAS) Q16595 (/TAS)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
2 O35943 (/ISO) O35943 (/ISO)
Negative regulation of organ growth GO:0046621
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
2 O35943 (/IMP) O35943 (/IMP)
Positive regulation of lyase activity GO:0051349
Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
2 Q16595 (/IDA) Q16595 (/IDA)
Positive regulation of lyase activity GO:0051349
Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
2 Q16595 (/IMP) Q16595 (/IMP)
Positive regulation of lyase activity GO:0051349
Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
2 O35943 (/ISO) O35943 (/ISO)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 Q16595 (/IDA) Q16595 (/IDA)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 O35943 (/ISO) O35943 (/ISO)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2 Q16595 (/IMP) Q16595 (/IMP)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2 O35943 (/ISO) O35943 (/ISO)
Positive regulation of succinate dehydrogenase activity GO:1904231
Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity.
2 Q16595 (/IMP) Q16595 (/IMP)
Positive regulation of succinate dehydrogenase activity GO:1904231
Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity.
2 O35943 (/ISO) O35943 (/ISO)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
2 Q16595 (/IMP) Q16595 (/IMP)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
2 O35943 (/ISO) O35943 (/ISO)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 D3ZYW7 (/NAS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q9W385 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q9W385 (/IMP)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 Q9W385 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 D3ZYW7 (/IEP)
Lipid catabolic process GO:0016042
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
1 Q9W385 (/IMP)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
1 Q9W385 (/ISS)
Axonal transport of mitochondrion GO:0019896
The directed movement of mitochondria along microtubules in nerve cell axons.
1 Q9W385 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 D3ZYW7 (/IEP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q9W385 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 D3ZYW7 (/IMP)
Positive regulation of heart contraction GO:0045823
Any process that activates or increases the frequency, rate or extent of heart contraction.
1 Q9W385 (/IMP)
Positive regulation of ecdysteroid biosynthetic process GO:0045998
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.
1 Q9W385 (/IMP)
Regulation of mitochondrial membrane potential GO:0051881
Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
1 Q9W385 (/IDA)
Positive regulation of oxidative phosphorylation GO:1903862
Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.
1 Q9W385 (/IDA)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 D3ZYW7 (/IDA) O35943 (/IDA) O35943 (/IDA) Q16595 (/IDA) Q16595 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O35943 (/HDA) O35943 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O35943 (/ISO) O35943 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q16595 (/ISS) Q16595 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q16595 (/NAS) Q16595 (/NAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q16595 (/TAS) Q16595 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q16595 (/IDA) Q16595 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O35943 (/ISO) O35943 (/ISO)
L-cysteine desulfurase complex GO:1990221
A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer.
2 Q16595 (/IDA) Q16595 (/IDA)
L-cysteine desulfurase complex GO:1990221
A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer.
2 O35943 (/ISO) O35943 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9W385 (/IMP)
L-cysteine desulfurase complex GO:1990221
A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer.
1 Q9W385 (/ISS)
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