The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Peptidase S8 propeptide/proteinase inhibitor I9
".
FunFam 5: Proteinase inhibitor I2B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
|
8 | O74989 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of proteolysis GO:0030162
Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
7 | P0CT04 (/IMP) P0CT04 (/IMP) P0CT04 (/IMP) P0CT04 (/IMP) P0CT04 (/IMP) P0CT04 (/IMP) P0CT04 (/IMP) |
|
Vacuole fusion, non-autophagic GO:0042144
The fusion of two vacuole membranes to form a single vacuole.
|
7 | P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) P0CT04 (/IDA) |
|
Protein catabolic process in the vacuole GO:0007039
The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases.
|
1 | O74989 (/NAS) |
|
Vacuole fusion, non-autophagic GO:0042144
The fusion of two vacuole membranes to form a single vacuole.
|
1 | O74989 (/ISO) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | O74989 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | O74989 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) |
|
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
|
7 | P0CT04 (/IPI) P0CT04 (/IPI) P0CT04 (/IPI) P0CT04 (/IPI) P0CT04 (/IPI) P0CT04 (/IPI) P0CT04 (/IPI) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) P0CT04 (/HDA) |
|
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
|
1 | O74989 (/ISO) |
