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CATH Superfamily 3.30.70.660

Pseudouridine synthase I, catalytic domain, C-terminal subdomain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pseudouridine synthase I, catalytic domain, C-terminal subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: tRNA pseudouridine synthase A

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA pseudouridine(38-40) synthase. [EC: 5.4.99.12]
tRNA uridine(38-40) = tRNA pseudouridine(38-40).
  • The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine.
  • TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures.
 14 A0A0E9CU68 A0A0E9CU68 A0A0E9DS84 A0A0E9DS84 A0A0E9DS84 B0B836 B0B836 B0B836 B0BCA1 B0BCA1
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